Mouse Transmembrane glycoprotein NMB(GPNMB) ELISA kit

Code CSB-EL009727MO
Size 96T,5×96T,10×96T
Trial Size 24T ELISA kits trial application
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Product Details

Target Name glycoprotein (transmembrane) nmb
Alternative Names Gpnmb ELISA kit; Dchil ELISA kit; Hgfin ELISA kit; NmbTransmembrane glycoprotein NMB ELISA kit; DC-HIL ELISA kit; Dendritic cell-associated transmembrane protein ELISA kit; Osteoactivin ELISA kit
Abbreviation GPNMB
Uniprot No. Q99P91
Species Mus musculus (Mouse)
Detection Range Request Information
Sensitivity Request Information
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Cancer
Troubleshooting
and FAQs
ELISA kit FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 7-14 working days

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Target Background

Function
(From Uniprot)
Could be a melanogenic enzyme.
Gene References into Functions
  1. Osteoactivin is a negative regulator of osteoclastogenesis in vitro and in vivo and this process is regulated through CD44 and ERK activation. PMID: 27585719
  2. M2 macrophages express significantly greater levels of OA/GPNMB than pro-inflammatory M1 macrophages. PMID: 26442636
  3. This is the first experimental study to show that GPNMB adversely influences myocardial remodeling. PMID: 28148779
  4. findings indicate that GPNMB promotes glioma growth via Na(+)/K(+)-ATPase alpha subunits. Thus, the interaction between GPNMB and Na(+), K(+)-ATPase alpha subunits represents a novel therapeutic target for the treatment of brain glioblastomas. PMID: 27836549
  5. Finally, we identify glycoprotein NMB as a melanocytic marker up-regulated in Tsc2-null mouse uteri and human lymphangioleiomyomatosis samples PMID: 26880751
  6. Study identified the Na+/K+-ATPase alpha 1 and 3 subunits as receptors for the extracellular fragment of GPNMB that mediates activation of cellular signaling pathways and subsequent neuroprotective effects. PMID: 26988030
  7. Genetic modulators of IOP thus may be independently identified using the full array of BXD mice without concern for the presence of transillumination defect or mutations in Typr1 and/or Gpnmb. PMID: 27011731
  8. The GPNMB is a promising biomarker and therapeutic target for the development and progression of Nonalcoholic fatty liver disease in obesity. PMID: 26581806
  9. macrophages infiltrating injured mucosa express Gpnmb, Gpnmbpositive macrophages may ameliorate inflammation in the intestinal mucosa. PMID: 26458492
  10. The present study, using mice, is the first to demonstrate that GPNMB improves both spatial and non-spatial memory PMID: 25545823
  11. Gpnmb Is a Potential Marker for the Visceral Pathology in Niemann-Pick Type C Disease PMID: 26771826
  12. Gpnmb-positive macrophages infiltrate the liver during the recovery phase of CCl4-induced acute liver injury. PMID: 26599547
  13. that osteoactivin overexpression has an osteoinductive effect on bone mass in vivo and stimulates osteoprogenitor differentiation ex vivo PMID: 25899717
  14. GPNMB has protective effect against ischemia-reperfusion injury via phosphorylation of ERK1/2 and Akt PMID: 25010402
  15. Glycoprotein nonmetastatic melanoma protein B plays an important role in angiogenesis during hyperoxia injury PMID: 25054912
  16. DC-HIL is the critical mediator of melanoma cells' suppressor function PMID: 24936834
  17. Osteoactivin is a matricellular protein that stimulates osteoblast adhesion through binding to alphav beta1 integrin and cell surface heparan sulfated proteoglycans, resulting in increased cell spreading, actin reorganization, and osteoblast differentiation. PMID: 24415158
  18. our results suggest that OA is able to induce transdifferentiation of myoblasts into osteoblasts through increasing levels of phosphorylated FAK. PMID: 24265122
  19. Results indicate that the DC-HIL/syndecan-4 (SD-4) pathway regulates autoimmune responses by mediating the T cell suppressor function of myeloid-derived suppressor cells (MDSCs). PMID: 24516197
  20. GPNMB inhibits motor neuron death and plays a critical role in motor neuron survival. PMID: 22891158
  21. SD-4, as the T-cell ligand of DC-HIL, is a potent inhibitor of allo-reactive T cells responsible for GVHD and a potentially useful target for treating this disease. PMID: 23113638
  22. Osteoclast-derived osteoactivin is a novel stimulator of osteoclast activity and bone resorption. PMID: 22536365
  23. R150X mutation in Gpnmb dramatically modified its list of genetic covariates, which may explain the associated ocular pathology. PMID: 21398278
  24. GPNMB influences the chemical composition of melanosomes. PMID: 21029394
  25. OA plays an important role in bone formation and serves as a positive regulator of fracture healing PMID: 20506259
  26. Gpnmb is a novel prorepair gene that is necessary for crosstalk between the macroautophagic degradation pathway and phagocytosis. PMID: 20709912
  27. ADAM10 as a sheddase capable of releasing the GPNMB/OA ectodomain from the surface of breast cancer cells PMID: 20711474
  28. DC-HIL/Gpnmb confers upon melanoma the ability to downregulate the activation of melanoma-reactive T cells, thereby allowing melanoma to evade immunologic recognition and destruction. PMID: 20570888
  29. mRNA of this gene is linked to the developing retinal pigment epithelium and iris in the embryo PMID: 12638126
  30. OA is expressed in late mouse embryonic development in the nervous system, basal layer of the skin, germinal cells of hair follicles, and in the forming nephrons of the kidney PMID: 14696968
  31. osteoactivin might function as an activator for fibroblasts infiltrated into denervated skeletal muscles and play an important role in regulating degeneration/regeneration of extracellular matrix PMID: 16100390
  32. Endogenous DC-HIL is a negative regulator of T lymphocyte activation PMID: 17284525
  33. GPNMB acts as a negative regulator of macrophage inflammatory responses. PMID: 17475886
  34. the role of Gpnmb in mechanisms involved in the subsequent IOP elevation and optic nerve degeneration remain unclear PMID: 17608931
  35. Syndecan-4 is the T cell ligand through which DC-HIL mediates its negative coregulatory function PMID: 17947650
  36. These results suggest that the extracellular fragments of osteoactivin produced by shedding act as a growth factor to induce MMP-3 expression via the ERK pathway in fibroblasts. PMID: 18036345
  37. Both OA-D and OA-E peptides significantly induced osteoblast differentiation in vitro and that effect is RGD independent. PMID: 18049427
  38. The inclusion of gpnmb in the MITF regulon suggests a role for GPNMB in mature osteoclast function. PMID: 18313864
  39. These findings indicate that osteoactivin is a novel osteoclastic protein and plays a role in osteoclast differentiation and/or activity. PMID: 18381073
  40. affects of Gpnmb on innate immunity influence susceptibility to glaucoma in DBA/2J mice PMID: 18402690
  41. Osteoactivin acts as a positive regulator of osteoblastogenesis. PMID: 18555216
  42. Gpnmb expression can be used as a marker for analyzing melanocyte development and disease progression. PMID: 18983539
  43. Gpnmb is a melanosome-associated glycoprotein that contributes to the adhesion of melanocytes with keratinocytes. PMID: 19320736
  44. Our findings support a dual role for DC-HIL: inhibition of adaptive immunity following ligation of syndecan-4 on activated T cells and induction of innate immunity against dermatophytic fungi. PMID: 19794069

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Involvement in disease May promote bone metastatic phenotype when overexpressed in breast cancer cells.
Subcellular Location Cell membrane, Single-pass type I membrane protein, Endomembrane system, Single-pass type I membrane protein, Cytoplasmic vesicle membrane, Single-pass type I membrane protein, Melanosome
Protein Families PMEL/NMB family
Tissue Specificity In early development, mRNA is detected at high levels in the outer layer of the retina. Later in development expression gets restricted to the retinal pigment epithelium and iris. Overexpressed in mammary cancer cells possessing a strong bone metastatic p
Database Links

KEGG: mmu:93695

STRING: 10090.ENSMUSP00000031840

UniGene: Mm.302602

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