Mouse apolipoprotein C-I (APOC1) ELISA kit

Unavailable
Code CSB-EL001930MO
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Product Type ELISA Kit
Size 96T,5×96T,10×96T
Uniprot No. P34928
Lead Time 7-14 working days
Abbreviation APOC1
Target Name apolipoprotein C-I (APOC1)
Species Mus musculus (Mouse)
Detection Range Request Information
Sensitivity Request Information
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Cardiovascular
Target Details This protein is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
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Function Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein (By similarity). Binds free fatty acids and reduces their intracellular esterification.
Subcellular Location Secreted
Protein Families Apolipoprotein C1 family
Tissue Specificity Adult and fetal liver.
Database Links

KEGG: mmu:11812

STRING: 10090.ENSMUSP00000045571

UniGene: Mm.182440

Pathway Cholesterol metabolism

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