Code | CSB-E14145m |
Size | 96T,5×96T,10×96T |
Price | Request a Quote or Start an on-line Chat |
Trial Size |
24T ELISA Kit Trial Size (Only USD$150/ kit) * The sample kit cost can be deducted from your subsequent orders of 96T full size kits of the same analyte at 1/5 per kit, until depleted in 6 months. Apply now |
This mouse GAS6 ELISA kit employs the quantitative sandwich enzyme immunoassay technique to measure the levels of mouse GAS6 in serum, plasma, or tissue homogenates. It also uses the enzyme-substrate chromogenic reaction to visualize and analyze the analyte levels through the color intensity. The intensity of the colored product is in direct proportion to the GAS6 levels in the sample and is measured at 450 nm through a microplate reader.
GAS6 is a vitamin K-dependent protein prominently expressed in endothelial cells, vascular smooth muscle cells, and bone marrow. It is involved in the regulation of several biological processes in cells, including proliferation, survival, migration, differentiation, adhesion, and apoptosis. GAS6 exerts these functions by binding to TAM receptors (Tyro3, Axl, and Mer). Vascular GAS6 upregulates tissue factors in vascular cells when vessel injury occurs, leading to activation of the extrinsic coagulation pathway and thrombus formation. When activated by GAS6, TAM receptors stimulate hemostasis by facilitating platelet stabilization. GAS6/TAM signaling is required for the proliferation and migration of cancer cells. GAS6 is overexpressed in melanoma, schwannoma, and glioma.
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