Mouse keratinocyte autocrine factor/Amphiregulin,KAF/AR ELISA Kit

Code CSB-E04497m
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Product Type ELISA Kit
Size 96T,5×96T,10×96T
Uniprot No. P31955
Lead Time 3-5 working days
Abbreviation AREG
Target Name amphiregulin
Alias AR, CRDGF, MGC13647, SDGF, colorectum cell-derived growth factor|schwannoma-derived growth factor
Species Mus musculus (Mouse)
Detection Range Request Information
Sensitivity Request Information
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Cancer
Target Details This protein is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype.
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Function Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.
Subcellular Location Membrane, Single-pass membrane protein
Protein Families Amphiregulin family
Database Links

KEGG: mmu:11839

STRING: 10090.ENSMUSP00000031325

UniGene: Mm.8039

Pathway ErbB signaling pathway
Hippo signaling pathway
MAPK signaling pathway
PI3K-Akt signaling pathway

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