||Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity).
|Gene References into Functions
- Two polymorphisms are identified in a single exon aafter comparaative sequencing analysis. PMID: 17651325
||Cell membrane, Single-pass type II membrane protein, Melanosome
||Peptidase M28 family, M28B subfamily