Rat Integrin beta-4(ITGB4) ELISA kit

Code CSB-EL011887RA
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Product Type ELISA Kit
Size 96T,5×96T,10×96T
Uniprot No. Q64632
Lead Time 5-7 working days
Abbreviation ITGB4
Protein Biological Process 1 Cell Adhesion
Target Name integrin, beta 4
Alias CD104, CD104 antigen|GP150|integrin beta 4|integrin beta-4 subunit
Species Rattus norvegicus (Rat)
Protein Biological Process 3 Cell adhesion
Sample Types serum, plasma, tissue homogenates, cell lysates
Detection Range 0.45 ng/mL-30 ng/mL
Sensitivity 0.11 ng/mL
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Signal Transduction
Protocol
Protocol may be improved. Please feel free to contact CUSABIO product specialist to obtain the latest version.
Target Details Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
HGNC 6158
RGD 2928
MGI 96613
References
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Function Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6
Subcellular Location Cell membrane, Single-pass type I membrane protein, Cell membrane, Lipid-anchor, Cell junction, hemidesmosome
Protein Families Integrin beta chain family
Database Links

KEGG: rno:25724

STRING: 10116.ENSRNOP00000059783

UniGene: Rn.198908

Pathway PI3K-Akt signaling pathway
Focal adhesion
Regulation of actin cytoskeleton

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