Rat ceruloplasmin (ferroxidase) (CP)ELISA kit

Code CSB-E17811r
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Product Type ELISA Kit
Size 96T,5×96T,10×96T
Uniprot No. P13635
Lead Time 3-5 working days
Protein Biological Process 2 Anion transport
Abbreviation ferroxidase
Protein Biological Process 1 Transport
Target Name ceruloplasmin (ferroxidase) (CP)ELISA kit
Alias CP-2, ceruloplasmin
Species Rattus norvegicus (Rat)
Protein Biological Process 3 Copper transport
Sample Types serum, plasma, tissue homogenates
Detection Range 15.6 ng/mL-1000 ng/mL
Sensitivity 3.9 ng/mL
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Signal Transduction
Protocol
Protocol may be improved. Please feel free to contact CUSABIO product specialist to obtain the latest version.
Assay Principle quantitative
Measurement Competitive
Target Details This protein is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities.
References
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Function Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. May also play a role in fetal lung development or pulmonary antioxidant defense. involved in iron transport across the cell membrane (By similarity). Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1.
Subcellular Location Secreted
Protein Families Multicopper oxidase family
Tissue Specificity Synthesized in liver and secreted into the plasma. Also choroid plexus, yolk sac, placenta, and testis; not in stomach and small intestine. Fetal lung and liver.
Database Links

STRING: 10116.ENSRNOP00000016083

UniGene: Rn.32777

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