| Gene References into Functions |
- VEGF and IL-8 play a prominent role in the pathogenesis of early forms of rosacea and the hemostasis system. PMID: 29578433
- High levels of LIFR in colorectal cancer (CRC) facilitated proliferation and migration of endothelial cells, resulting in an increase in angiogenic activity. Moreover, IL-8 was found to play a role in the LIFR induced angiogenesis. IL-8 levels were correlated with LIFR levels in CRC tissues, whereas depletion of IL-8 led to a reduced angiogenic activity of LIFR in CRC cells. PMID: 29751081
- PKC-delta isoform plays a crucial role in Tat-TLR4 signaling pathway to activate NF-kappaB and CXCL8 production. PMID: 28539656
- CXCL8 was a target of miR-204, and miR-204 suppression could not increase cell viability, migration, invasion, and EMT procedure when CXCL8 was silenced. PMID: 29402343
- Interleukin 8 - 845 T/C and + 781 C/T polymorphisms were analyzed. For + 781C/T locus, in the dominant genetic model, significant difference between TT vs. CC + CT genotypes that significantly had a protective role against periodontitis disease. Positive association between distribution of IL8 - 845 T/C alleles and risk of periodontitis disease. C allele of IL-8 - 845 increased the risk of periodontitis disease. PMID: 30078118
- These results suggest a direct involvement of IL-8-CXCR1/2 axes in GBM progression by promoting both cell proliferation and invasion and indirectly by promoting neovascularization in the form of vascular mimicry. PMID: 30086759
- These results show that AKIP1 is crucial in cervical cancer angiogenesis and growth by elevating the levels of the NF-kappaB-dependent chemokines CXCL1, CXCL2, and CXCL8. PMID: 29520695
- The extramembranous domain of HofQ (emHofQ) was shown to interact with various cytokines, of which IL-8 exhibited the strongest interaction. PMID: 30088437
- he protein expression levels of IL-8 were significantly decreased in SZ patients, but no significant difference in the mRNA levels of IL-8 was observed between SZ patients and NC subjects. PMID: 28476335
- immune system process is indispensable in the progression of disease in colon, and identifies that IL-8 and MMP-9 play potential critical roles for the progression. PMID: 30074183
- IL-8 production was significantly enhanced following treatment with both IL-17A and CSE, while treatment with either IL-17A or CSE alone caused only a slight increase in IL-8 production. PMID: 29463070
- Work identified IL-8 as a positive regulator of homotypic CIC formation via enhancing intercellular adhesion. PMID: 30021676
- V2O5 induction of CXCL8 and CXCL11 chemokines may lead to the appearance and perpetuation of an inflammatory reaction into the dermal tissue. Further studies are required to evaluate dermal integrity and manifestations in subjects occupationally exposed, or living in polluted areas. PMID: 29901202
- Study findings point out that PAR2 could play an essential role in gastroesophageal reflux disease (GERD) pathogenesis - even repeated short-term exposure to weakly acidic conditions lead to the upregulation of PAR2 and subsequent activation of the intense IL-8 release in the esophageal mucosa and initiation of mucosal immune response in GERD. PMID: 29672302
- Given that IL-8, MIP-1beta, and MCP-1 are chemokines that play important roles in recruitment of immunocompetent cells for immune defense and tumor cell clearance, the observed lower levels of these markers with increasing PM2.5 exposure may provide insight into the mechanism by which DEE promotes lung cancer. PMID: 29023999
- These results suggested that stemness induction in SKOV3 cells by macrophages co-cultured with SKOV3-derived OCSLCs involved IL-8/STAT3 signaling. PMID: 29656182
- IL-8-251T>A (rs4073) Polymorphism is associated with gastric Cancer. PMID: 30275190
- expression level of CXCL8 had a positive relationship with recurrence probability in Acute myeloid leukemia. PMID: 29596823
- These data were in close agreement with the reduced cell migration and colony formation. Results from the present study suggested that reparixin and SCH527123 may be promising therapeutic agents for the treatment of pancreatic cancer by inhibiting the IL8/CXCR1/2 signaling cascade. PMID: 29749433
- A urinary IL-8 level of less than 61.25 pg/ml is more sensitive for prediction of complete remission in idiopathic membranous nephropathy patients. PMID: 29415357
- berberine inhibited the expression of MCP-1 and IL-8 induced by LPS. PMID: 28852897
- Regarding the IL-8 promoter T - 251A, the TA and AA genotypes were associated with significantly decreased risks of nasopharyngeal carcinoma (NPC) in a Taiwanese population compared with the wild-type TT genotype. The mRNA and protein expression levels for NPC tissues revealed no significant associations among the 20 NPC samples with different genotypes. PMID: 30200105
- IL-8 +781 T/C polymorphism is associated with the severe Clostridium difficile infection PMID: 29203364
- ShRNA mediated down-regulation of CXCL8 resulted in inhibition of cell proliferation, viability and invasion in vitro and a near complete growth reduction of tumor in vivo. PMID: 29679563
- CSF IL-8 concentrations were significantly elevated in CNS tumor patients as compared to non-tumoral individuals. AUC for CSF IL-8 was higher than for its index (CSF IL-8/serum IL-8). PMID: 29086194
- High IL8 expression is associated with melanoma. PMID: 29286146
- Lipo-CPFX, but not CPFX, retained the anti-IL-8 releasing activity. PMID: 29337216
- The results indicate significant contribution of IL8 on survival of hormonal dependent early-stage breast cancer patients and association with established parameters such as estrogen receptors/progesterone receptor and HER2. PMID: 28569250
- the frequency of non-classical monocytes expressing CXCL8 was increased in systemic sclerosis patient and monocytes expressing CXCL8 PMID: 29127442
- ntermediate Molecular Mass Hyaluronan and CD44 interactions enhanced normal PMN phagocytosis and IL-8 production PMID: 28730511
- serum levels in active vitiligo significantly elevated compared to those in stable vitiligo patients PMID: 29115683
- High IL8 expression is associated with pancreatic adenocarcinoma. PMID: 29205349
- Compared with controls, the interleukin (IL)-8 A/A genotype was more common in acute pancreatitis (AP). PMID: 29215544
- The presence of neither the first transmembrane helix of the receptor nor the lipid bilayer significantly affected the interactions of IL-8 with Binding Site-I of CXCR1. PMID: 29143165
- CXCL8 is highly expressed in cervical cancer tissues and cell lines, and correlated with malignant status and prognosis in cervical cancer patients. PMID: 28883082
- In conclusion, to our knowledge, this is the first study in the association of rs4073 and rs2227306 polymorphisms with childhood asthma risk in the Tunisian population. PMID: 28993876
- Results show that IL8 expression level is regulated by APE1 which activates NF-KB. PMID: 27388124
- aberrant miR-520c-3p expression may lead to reduced IL-8 expression and promote the mesenchymal phenotype in breast cancer cells, thereby increasing invasive growth. PMID: 29048659
- increased levels of IL-8 are associated with factors of worse prognosis in ovarian cancer PMID: 28872976
- Significantly elevated blood levels of IL-8 in myelodysplastic syndrome patients. PMID: 28856536
- the elevated concentrations of CXCL13, CXCL8, and CXCL10 or their increasing CSF/serum ratios may be potential biomarkers of neurosyphilis PMID: 27650493
- Results implicated the important role of PRL-3 in glycolysis metabolism through improving IL-8 secretion in colorectal cancer cells, and PRL-3 mediated glycolysis contributed to the promotion of cancer metastasis. PMID: 28791350
- Changes in serum IL-8 levels could be used to monitor and predict clinical benefit from immune checkpoint blockade in melanoma and NSCLC patients PMID: 28595336
- Lung cancer patients showed significantly lower levels of serum VEGF (1.9 fold) and IL-8 (~9 fold) than COPD patients. VEGF level was significantly higher (2.6 fold) in metastatic than non-metastatic cancer patients. An increase in MMP-9 (~1.6 fold) levels was observed in lung cancer patients. PMID: 27811960
- CXCL1/8 secreted by adipose-derived mesenchymal stem cells could promote breast cancer angiogenesis. PMID: 28514506
- our meta-analysis suggests that the IL-8 rs4073, A2767T, T11722T2, rs2234671, rs2230054, rs1126579, rs2227306, rs2227307, rs2227532, and T-738A polymorphisms are not associated with periodontitis while the IL-8 C1633T and rs1126580 polymorphisms may elevate the susceptibility of periodontitis based on the currently available evidences. PMID: 28446725
- An analogue of human CXCL8, CXCL8(3-72)K11R/G31P (hG31P) has been developed. PMID: 28754019
- inflammation triggered property of Microcystin-LR via IL-8/CXCR2 signaling PMID: 29197248
- A high IL-8 content in urine sampled on day 1 after renal transplantation was positively correlated with the activity of metalloproteinase-9 in urine. This proves that both of these chemokines cooperate in ischaemia-reperfusion injuries in transplanted kidneys. PMID: 28494217
- We discovered that IL-8 secreted from decidual stromal cells is a key cytokine enhancing the invasiveness of trophoblasts PMID: 28328096
- these findings demonstrated that poly I:C accelerated collective HaCaT cell migration via autocrine/paracrine secretions of IL-8 and the subsequent incomplete epithelial-mesenchymal transition PMID: 28438134
- Blocking of GPR68 or NF-small ka, CyrillicB activity severely attenuated acidification induced IL-8 production. PMID: 27166427
- Suggest that an increased concentration of IL-8 is associated with resting pain in rotator cuff tear patients. PMID: 25930944
- The results of the transwell chemotaxis assay also supported the above results. Our data suggest that APN can promote h-JBMMSC chemotaxis by up-regulating CXCL1 and CXCL8 PMID: 28176455
- IL-8 has an important role in HNSCC progression via CXCR1/2-mediated NOD1/RIP2 signaling PMID: 27557518
- We suggest that a combination of H. pylori infection and the IL-8 -251 T > A polymorphism might increase the risk of severe AG and GC in a Korean population PMID: 28558668
- Knockdown of IL-8 Provoked Premature Senescence of Placenta-Derived Mesenchymal Stem Cells.( PMID: 28418782
- IL-33 induces IL-8 expression via JNK/c-Jun/AP-1 pathway in human vascular endothelial cells, and provides a new insight into the role of IL-33-induced IL-8 in the pathophysiology of atherosclerosis and vascular inflammation PMID: 29373608
- these findings indicate that leptin may promote tumor growth and metastasis by stimulating IL-8 production in tumor-associated macrophage PMID: 27588409
- Up-regulation of IL-8 and its association with the marker of clinical and inflammatory activity, CRP, suggest a role of this cytokine in the pathogenesis of chronic spontaneous urticaria. PMID: 29254299
- data obtained suggests the importance of IL-8 in the direct regulation of adaptive T cell reactivity PMID: 28667886
- sohlh2 functions as a tumor metastasis suppressor via suppressing IL-8 expression in breast cancer PMID: 27384482
- Claudin-5 was shown to be regulated VEGFR2/PI3K-Akt dependently by VEGF and PI3K-Akt independently by histamine. Interleukin-8 was shown to downregulate claudin-5 by histamine. PMID: 27873103
- Levels of IL-8 in CSF were significantly higher in multiple sclerosis (MS) patients than in controls. Serum levels of IL-8 were significantly lower in MS patients than in controls. PMID: 28619424
- Association of polymorphic markers of chemokine genes, their receptors, and CD14 gene with coronary atherosclerosis PMID: 29369549
- gene polymorphisms of IL-8(-251T/A) and IP-10(-1596C/T) are associated with susceptibility and progression of type 2 diabetic retinopathy in a northern Chinese population PMID: 27935598
- Recombinant OmpU (rOmpU) of V. cholerae induced IL-8 expression at the mRNA and protein levels in a dose- and time-dependent manner in HT-29 cells. IL-8 was secreted through both apical and basolateral sides of the polarized HT-29 cells upon apical exposure to rOmpU but not upon basolateral exposure. PMID: 29145158
- that the mRNA expression of the chemokine IL-8 is significantly lower in samples from interstitial fibrosis/tubular atrophy patients than in samples from patients with stable graft function PMID: 27693310
- Study provides evidence that IL-8 promotor is activated by the binding of RELA to TWIST1. PMID: 28283022
- In this review, we summarize the biological functions and clinical significance of the CXCL8-CXCR1/2 signaling pathway in cancer. Targeting CXCL8 or CXCR1/2 may be an attractive therapeutic strategy for tumors. PMID: 27578214
- IL-8 has a role in lung carcinoma resistance to erlotinib PMID: 27248176
- USP21 binds to the promoter region of IL-8 and mediates transcriptional initiation, which regulates the stem-cell like property of human renal cell carcinoma PMID: 27259257
- Relationship of inflammatory profile of elderly patients serum and senescence-associated secretory phenotype with human breast cancer cells proliferation: Role of IL6/IL8 ratio.( PMID: 27951455
- in the presence of autologous platelets, monocytes from older adults synthesized greater IL-8 than younger adults PMID: 29167233
- The mo-DCs from HIV-1 infected patients depicted functional exhaustion as evident by decreased allo-stimulation index (mean+/-SD: 10+/-6 vs. 24+/-16) (p<0.05), decreased cytokine production (pg/ml) (IL-12: 4.6+/-16 vs. 25+/-85; TNF-alpha: 128+/-279 vs. 286+/-544; IL-10: 6+/-12 vs. 13+/-20; IL-8: 10,688+/-11,748 vs. 17,470+/-125,049) and retained endocytosis (1.1+/-0.3 vs. 1.0+/-0.29) (p<0.05) even after LPS-stimu... PMID: 28056393
- Interaction of Monomeric Interleukin-8 with CXCR1 PMID: 29262362
- lactobacilli from the omnivorous group and all bifidobacteria significantly down-regulated IL-8. Notably, both genera also lowered the TSLP expression in stimulated Caco-2 cells, regardless of the diet regimen. PMID: 27863334
- The serum levels of IL-8, MIP-1 alpha, MIP-1 beta, MMP-8, Resistin, FLRG, and BCAM were significantly higher in breast cancer patients, but LAP and TSH-beta levels were lower. PMID: 26898119
- Oral and periodontal innate immunity is affected by HIV viremia and ART. GCF IL-8, G-CSF, as well as serum IL-8, MCP-1 and GM-CSF may be useful biomarkers for the detection of disease presence and/or its severity due to HIV infection and ART use. PMID: 28043030
- first study to investigate the concentrations of CXCR-1 and CXCR-2 with the levels of IL-8 in colostrum and mature human milk of term and preterm newborns PMID: 27105439
- lithocholic acid activated Erk1/2 and in turn, suppressed STAT3 phosphorylation to induce IL-8 expression in HCT116 cells, thus stimulating endothelial cell proliferation and tube like formation. PMID: 28247965
- CD109 knockdown upregulated IL-8 expression through activation of TGF-beta/Akt/NF-kappaB pathway in human umbilical vein endothelial cellsk PMID: 27121053
- Strawberry tannins inhibit IL-8 secretion in a cell model of gastric inflammation. PMID: 27473819
- The greater aggressiveness of bcl-xL-overexpressing melanoma cells was mediated by an autocrine effect of CXCL8 on its CXCR2 receptor, as confirmed by an shRNA approach. PMID: 28949016
- The strongest OR was for CXCL8 (interleukin-8) in serum (96.8, 95% CI: 11.9-790.2). Of these 15 markers, 6 were also significantly elevated in serum from Chile (CCL20, C-reactive protein, CXCL8, CXCL10, resistin, serum amyloid A). PMID: 27173614
- IL-8, but not the CXCL1 circuit, is critical for the regulation of thyroid cancer stem cells. PMID: 27577959
- IL-8 A-251 TT genotype may contribute to the differentiated thyroid carcinoma lymph node metastasis. PMID: 28164553
- Taken together, the data presented here suggest that TLR2 activation in human mast cells promotes the release of inflammatory mediators via distinct signaling pathways that partially depend on the action of Go proteins. PMID: 27515449
- ERRalpha can trigger the proliferation and migration of colorectal cancer cells via up regulation of IL-8. PMID: 28993941
- elevated intracystic il-8 levels are associated with worse prognosis in ovarian cancer PMID: 28960399
- Elevation of IL8 in bile of primary sclerosing cholangitis (PSC) patients, collected at different stages of disease, indicates an ongoing inflammatory stimulus that drives IL8 production. This challenges the idea that advanced PSC is a burned-out disease, and calls for reconsideration of anti-inflammatory therapy in PSC. PMID: 26866350
- Diagnostic value of sTREM-1, IL-8, PCT, and CRP in febrile neutropenia after autologous stem cell transplantation PMID: 28920169
- PROX1 activated nuclear factor kappaB signaling and selectively promoted expression of the proangiogenic interleukin-8 by epigenetically stimulating the IL-8 promoter. PMID: 28646551
- High IL8 expression is associated with alcoholic hepatitis. PMID: 28818508
- data showed that HDAC1 can trigger the proliferation and migration of breast cancer cells via activation of Snail/IL-8 signals PMID: 28779562
- ATP-induced IL-8 release maybe involved in the pathogenesis of refractory gastroesophageal re fl ux disease. PMID: 27977904
- Data suggest that primary cells from papillary renal cell carcinoma secrete the chemokines IL8, CXCL16, and chemerin; these chemokines attract primary human monocytes and induce shift/transdifferentiation in monocytes toward M2 macrophage/foam cell phenotype. (IL8 = interleukin-8; CXCL16 = C-X-C motif chemokine ligand 16) PMID: 28759013
- findings strongly suggest that P. gingivalis infection plays an important role in the promotion of the invasive potential of oral squamous cell carcinoma cells via the upregulation of IL-8 and MMPs. PMID: 27468958
- miR-424-5p expression in oral squamous cell carcinoma cells could be induced by IL-8 through increasing STAT5 transcriptional activity. PMID: 27038552
- IL-8 in serum is a predictor of short-time mortality in patients with acute hypercapnic respiratory failure and acute exacerbation of COPD treated with noninvasive positive pressure ventilation. PMID: 28178959
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