CD34 Monoclonal Antibody

Code CSB-MA918107
Size US$350
The deliverables will contain a corresponding secondary antibody if ordered this antibody. 
Image
  • IHC image of CSB-MA918107 diluted at 1:100 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-mouse IgG polymer labeled by HRP and visualized using 0.05% DAB.
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Product Details

Full Product Name Mouse anti-Homo sapiens (Human) CD34 Monoclonal antibody
Uniprot No. P28906
Target Names CD34
Alternative Names CD34 antibody; CD34 antigen antibody; CD34 molecule antibody; CD34_HUMAN antibody; Cluster designation 34 antibody; cluster of differentiation 34 antibody; Hematopoietic progenitor cell antigen CD34 antibody; HPCA1 antibody; Mucosialin antibody; OTTHUMP00000034733 antibody; OTTHUMP00000034734 antibody
Raised in Mouse
Species Reactivity Human
Immunogen Synthesized peptide derived from human CD34
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Monoclonal
Isotype IgG1, Kappa
Purification Method The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Tested Applications ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.
Gene References into Functions
  1. This study aimed to confirm and analyze lymphovascular invasion (LVI) detected by hematoxylin and eosin (H and E) using IHC with CD34 and D2-40 and its correlation with other biologic and morphologic prognostic markers. D2-40 is a promising marker for lymphatic endothelium. LVI is a poor prognostic marker hence should be evaluated imperatively in all cases of carcinoma breast. PMID: 29567882
  2. The role of CD34 in determining the premalignant nature of ral submucous fibrosis (OSF) could not be ascertained, since all endothelial cells were positive for CD34, whereas CD105 appeared to be more specific as it is associated with hypoxia-induced angiogenesis which is occurring in OSF due to hyalinization suggesting, CD105 to be more specific marker to determine neoangiogenesis in OSF PMID: 30197335
  3. EZH2, ET-1, and CD34 may act as biomarkers of aggressive cervical squamous cell carcinoma PMID: 29630085
  4. The effects of Platelet-rich plasma on vascular endothelial growth factor receptor-2 (VEGFR2) and CD34 expression were evaluated using real-time PCR, flow cytometry, western blot, immunocytochemistry and pathological study, as were carried out in both human umbilical endothelial cell culture and rat skin PMID: 28948378
  5. Disruption of GFI1B non-DNA-binding zinc-finger 1 is associated with mild to moderate thrombocytopenia without alpha-granule deficiency or bleeding symptomatology, indicating that the site of GFI1B mutation has important phenotypic implications. Platelet CD34 expression appears to be a common feature of perturbed GFI1B function. PMID: 28880435
  6. The endometrial expression of LIF and CD34 in the pathogenesis of non-developing pregnancy can be used for evaluating the pregnancy prognosis in women of young and old reproductive age. PMID: 29063331
  7. In summary, this study shows that CD34 plays a role during cell cycle progression of head and neck squamous cell carcinoma and additionally is involved in irradiation resistance and differentiation of malignant oral keratinocytes. PMID: 27837456
  8. Report CD34 expression in dermatofibromas and dermatofibrosarcoma protuberans. PMID: 28832078
  9. CD34+ clusters showed more important prognostic impact on survival and progression to leukaemia. PMID: 28669578
  10. Our findings showed that increased expression of CD34 and CD117 markers confer tumor progression and aggressiveness on prostate cancer. PMID: 28552539
  11. CD34(+) and CD34(-) cells are different phenotypes of similar cells, and CD34 (1) can be regulated in endothelial colony-forming cells ECFC; (2) is positively involved in capillary-like sprout formation; (3) is associated but not causally related to tip-cell gene expression; and (4) can affect endothelial barrier function. PMID: 27043316
  12. Studied levels of peripheral blood CD34(+ )cells in women who subsequently had a spontaneous miscarriage (SM). Found CD34 positive B cells were significantly lower in SM group compared to control group. PMID: 28110587
  13. The number of platelets and circulating CD34-positive cells acts as an indicator of the activity of the vicious cycle that exists between hypertension and endothelial dysfunction in elderly Japanese men. PMID: 28282559
  14. ESAT-6, an essential virulence factor of Mycobacterium tuberculosis, may contribute to the abnormal hematopoiesis of tuberculosis patients by inhibiting the proliferation and differentiation of CD34-positive hematopoietic cells via apoptosis. PMID: 27745787
  15. Intramyocardial autologous CD34(+) cell administration improved exercise tolerance in patients with refractory angina. PMID: 27491607
  16. Increased gene expression linked to the proinflammatory TGFbeta and MAPK signaling pathways were detected in CD34(+) cells of myeloproliferative neoplasm patients. PMID: 27341002
  17. CD34 stem cell exosomes mediate ischemic tissue repair via beneficial angiogenesis. Exosome-shuttled proangiogenic miRNAs may amplify stem cell function. PMID: 28298297
  18. miR-378 regulates the angiogenic capacity of CD34(+) progenitor cells in STEMI patients. PMID: 28062497
  19. CD34 and IL-8 are associated with poor prognosis of melanoma, metastasis, and neoangiogenesis PMID: 27175552
  20. The results showed that transfection of CD34(+) cells with SiRNA targeting TGF-bRII and their co-culture with human bone marrow mesenchymal stromal cells (MSCs) could considerably increase the number of progenitors PMID: 27344285
  21. Expression of CD34 and MMP-9 accurately predicts clinical behavior detection and prognosis of GCTBs. PMID: 27384731
  22. Expression of VEGF and CD34 was critically correlated with perioperative hemorrhage in gastric cancer patients. PMID: 27503021
  23. There was significant correlation between age and tumor size with CD34 expression in oral SCC samples and no significant correlation between sex and tumor differentiation level. Also, there was no significant correlation between age, sex, tumor size and tumor differentiation level (grading) with CD34 expression in esophagus SCC samples. PMID: 26323448
  24. Normal FLT3 and negative expression of CD34 and cMPL may predict a longer overall survival in aute myeloid leukemia. PMID: 27993871
  25. High VEGF expression was subsequently correlated with a short overall survival rate for patients exhibiting lymph node metastasis (P=0.0128); however, there was no significant difference in overall survival rate regarding the expression levels of TP and CD34 PMID: 26676225
  26. Metformin simultaneously increases VEGFA and reduces CXCL10 and TIMP1 in CD34(+) cells in a model of the diabetic state combined with hypoxia to stimulate angiogenesis. PMID: 26861446
  27. Immunohistochemistry results indicate that combination with ALDH1 and STAT6 can improve the diagnostic value of CD34 for solitary fibrous tumors. PMID: 26617768
  28. CD34(+) cells lowering expression of TET2 may play an oncogenic role on myeloid tumor and CD3(+) T cells of myelodysplastic syndrome patients may be derived from the malignant clone. PMID: 26617797
  29. ICAM-1, VCAM-1 and CD34 are useful biomarkers in evaluation of vascular and inflammatory lesions such as gingival pyogenic granuloma and the results indicate the role of these biomarkers in pathogenesis of oral pyogenic granuloma. PMID: 26625754
  30. Studied the relationship between serum alkaline phosphatase, circulating CD34-positive cells and body mass index. PMID: 26769093
  31. Autophagy in CD34+ cells from aplastic anemia patients is impaired; autophagy is required for the survival of CD34+ cells; impaired autophagy in CD34+ hematopoietic progenitor cells may play an important role in the pathogenesis of aplastic anemia. PMID: 26930650
  32. overexpression in glioma tissues associated closely with higher WHO grade (III + IV) [review] PMID: 26886640
  33. Asthmatics with reduced lung function had a higher frequency of Lin(-) CD34(hi) CD117(int/hi) Fc epsilon RI(+) blood mast cell progenitors than asthmatics with normal lung function. PMID: 26626992
  34. Our results suggest that the CD34/CD25/CD123/CD99(+) LAIP is strictly associated with FLT3-ITD-positive cells. PMID: 25957287
  35. Data indicate only the glycoproteins CD34+/CD71low population showed statistically significant differences between Diamond-Blackfan Anaemia (DBA) patients and controls. PMID: 26394034
  36. We here identify CD49f and CD34 as markers to permit selection of the stem/progenitor cell-like population from human myometrium PMID: 26108791
  37. CD34 expression in the placental endothelial cells was stable throughout pregnancy. PMID: 25043745
  38. Autologous CD 34(+) cell infusion is safe and effectively improves liver function in the short term and may serve as a bridge to liver transplantation. PMID: 26109814
  39. Higher percentages of CD34 + CD38- cells in apheresis products reflect inadequate in vivo purging and reliably distinguish samples enriched in LSCs from those involving mainly normal cells. PMID: 24884314
  40. The number of CD34/144 positive circulating endothelial cells was high in patients with large artery atherosclerosis who experienced chronic ischemic stroke. And this number may reflect severity of carotid atherosclerosis. PMID: 25542764
  41. The evaluation of both CD34-CD105 showed the role of angiogenesis in the cancer proliferation and local spread, the angiogenesis level being maintained high even in the advanced stages of the disease. PMID: 26193208
  42. There were significant differences in CD34 expression between papillary thyroid hyperplasia, papillary thyroid carcinoma, and papillary thyroid lesions of uncertain malignant potential. PMID: 25921136
  43. lack of predictive factors for CD34(+) cells and total nucleated cell concentrations in umbilical cord blood samples before processing PMID: 25446160
  44. The number of CD34(+) cells in bone marrow was significantly higher compared to the number of CD34(+) cells in peripheral blood cells and increased with the acquisition of leukemic cells the resistance to imatinib. PMID: 25804236
  45. CD34 and CD49b are cell surface markers that can be used to enrich a subpopulation of leiomyoma cells possessing stem/progenitor cell properties. PMID: 25658015
  46. no difference in expression between normal and pathologically immature placentas PMID: 25149387
  47. Report CD34/MMP7 expression and invasiveness in early colorectal neoplasms using narrow band imaging and immunohistochemistry. PMID: 25357219
  48. Angiogenic factors VEGF, HIF-1alpha and CD34 are important in breast cancer progression and their abundance in breast tumors has prognostic and predictive value. PMID: 23899963
  49. Combinatorial expression of NKX2-5, SIRPA, VCAM1 and CD34 can be used to define discrete stages of cardiovascular cell lineage differentiation. PMID: 24968096
  50. In MLL-AF4 patients, CD34(+)CD38(+)CD19(+) and CD34(-)CD19(+) cells initiated leukemia. PMID: 25538041
  51. Establishment of Ki67, p53 and CD34 expression in human tooth buds of different stages of odontogenetic development. PMID: 24715164
  52. Increases in CD34(+)CD38(-)CD123(+) cells may reflect malignant clonal cells with aberrant differentiation, overproliferation, and decreased apoptosis in myelodysplastic syndrome, which were similar to acute myeloid leukemia. PMID: 24846193
  53. Inflammatory status in rheumatoid arthritis is associated with an increased expression of TLR3 and of IL-1beta in CD34+ cells, which appear to affect cell number. PMID: 25436985
  54. for the cytological diagnosis of angiosarcomas, ERG and CD31 are more sensitive vascular markers than CD34 PMID: 25352641
  55. Increased bone marrow CD34(+) percentage was associated with improvement in left ventricular ejection fraction. PMID: 25136078
  56. Expression of endothelial marker molecules in CD34+cells was significantly induced in the polytrauma patients. PMID: 24826895
  57. The isolated expression of CD34 identifies a group of classic acute promyelocytic leukemia patients with negative prognosis. PMID: 24912771
  58. Our data reveal that a high proportion of CD34+/CD38- cells is positively associated with a poor prognosis of childhood ALL, to further guide therapy of the disease. PMID: 23706103
  59. Suggest RepSox may reduce Tim-3 expression by inhibiting transforming growth factor-beta signaling and slow decay of CD34(+) AML cells by increasing CXCL12 and MYC, two factors that inhibit AML cell differentiation. PMID: 24855276
  60. Data suggests that plerixafor "on demand" may be considered in patients with myeloma and lymphoma with delayed hematopoietic recovery and < 10/muL CD34+ cells, as a first-line mobilization strategy. PMID: 23656194
  61. Data indicate there is a pool of CD34/CXCR4+ stem cells circulating in large number in peripheral blood of acute myocardial infarction patients post infarction together with low CXCR4 expression on these cells. PMID: 25204042
  62. Cellular structures such as the spherical shape and microvilli of CD34+ cells may also contribute to regulation of cell adhesion. PMID: 24036614
  63. There was variable loss of CD34 immunoreactivity in older donor eyes. PMID: 24466138
  64. CD34 antibody is a good endothelial marker for hepatic carcinogenesis. PMID: 24507660
  65. Evaluation of the microvessel density with CD34 and CD105 markers is not useful in forecasting survival rate and disease recurrence in patients with ovary cancer. PMID: 24364465
  66. CD34 expression in the capillaries and sinusoids of noncancerous hepatic tissue is a risk factor for multicentric recurrence of hepatocellular carcinoma. PMID: 24281022
  67. The level of CD34+CD133+ endothelial progenitor cells probably serves as a predictor of the development and severity of atherosclerosis on a cellular level. PMID: 24335569
  68. JC polyomavirus DNA may infect CD34+ cells in the bone marrow of patients with multiple sclerosis (MS), may then mobilize in mononuclear cells circulating in MS patients treated with natalizumab who thus harbor JCV DNA. PMID: 24664166
  69. Mitochondrial mass correlates strongly with mitochondrial membrane potential in CD34+ hematopoietic stem/progenitor cells. PMID: 23349299
  70. HIF1-alpha and CD34 are expressed differently in esophageal squamous cell carcinoma and adenocarcinoma, suggesting different mechanisms PMID: 23653235
  71. There was a statistically significant inverse association of CD34 expression with adverse histological features, and a positive correlation of VEGF and cytoplasmic beta-catenin staining with unfavourable microscopic parameters in breast phyllodes tumors. PMID: 23772632
  72. [review] Circulating CD34+/KDR+/CD45dim endothelial progenitor cells have great potential as biomarkers in various cardiovascular diseases. PMID: 23171577
  73. Data indicate that microvessel density (MVD) were obtained for both miRNA-126 and CD34 by quantitative image analyses. PMID: 23838926
  74. The flow cytometry system based on immunophenotyping in CD34+ blasts is a useful and simple tool for diagnosis and prognosis evaluation in myelodysplastic syndromes . PMID: 23554290
  75. As a short-term effect, PDI seems to inhibit myofibroblastic transformation of keratocytes, but does not have an impact on activation of CD34-positive keratocytes. PMID: 23794425
  76. An increased number of CD34+ cells is found in both upper and the lower dermis of patients following localized scleroderma treatment. PMID: 23645504
  77. Report CD34 expression in embryonic gut stem cells and suggest that gastrointestinal stromal tumor may arise from these cells. PMID: 23696920
  78. Data suggest that circulating CD34/VEGFR3 are biomarkers for epithelial ovarian cancer (EOC); circulating bone marrow-derived lymphatic/vascular endothelial progenitor cells are significantly increased in EOC and correlate with lymph node metastasis. PMID: 23803010
  79. Co-culture of CB CD34(+) cells with mesenchymal stromal cells, especially in the absence of cytokines, maintained mRNA expression of p21 and p57 genes in ex vivo expanded CD34(+) cells. PMID: 22980580
  80. In patients with dilated cardiomyopathy, transendocardial CD34-expressing cell transplantation is associated with higher myocardial retention rates and greater improvement in ventricular function. PMID: 24030420
  81. CD34 expression predicts an adverse outcome in patients with NPM1-positive acute myeloid leukemia. PMID: 23701943
  82. human cord blood-derived CD34(+) cells in collagen I-based hydrogel containing cytokines promote stem cell proliferation and protect these cells from anoxia-induced apoptosis PMID: 23509738
  83. CD34+ mononuclear cell mobilization is significantly impaired in patients with recurring atrial fibrillation after radiofrequency catheter ablation. PMID: 21640411
  84. A significant reduction in the number of CD34+ cells was shown in subjects with diabetes mellitus and end stage renal disease. PMID: 23625296
  85. In vitro mast cell differentiation was associated with decreased CD34 expression and increased HIF1A expression. PMID: 23529663
  86. Suggest that niche-supporting CD34- cells facilitate cell survival, angiogenic cytokine secretion, and incorporation capacity, and preserve the progenitor status of endothelial colony forming cells. PMID: 23640491
  87. Data indicate that long-term self-renewing leukemic stem cells reside within the CD34(+)/ITGA6(+) fraction. PMID: 23233446
  88. CD34 expression on blasts is a novel, poor predictor independent of FlT3-ITD in NPM1-mutated acute myeloid leukemia patients. PMID: 23473998
  89. MASL1 expression is upregulated during primary human CD34+ cell erythroid differentiation and is an abundant protein in human red blood cells. PMID: 23327923
  90. The paucity of CD34-positive cells in acute coronary thrombi from patients with type 2 diabetes mellitus could facilitate thrombus formation. PMID: 22862965
  91. Bladder cancer CD34 microvessel density is associated with recurrence after BCG immunotherapy. PMID: 22574784
  92. Data indicate taht a lack of CD34 expression in tumors was found to be related to cystic degeneration after imatinib treatment. PMID: 22952296
  93. Sema7A markedly reduces the production rates of megakaryocytes and platelets from CD34(+) progenitor cells. PMID: 22448926
  94. Frequent desmin (32%) and occasional CD34 (6%) expression are encountered in cellular fibrous histiocytoma. PMID: 22775584
  95. Review: evidence for the clinical usefulness of CD34(+) cells in the treatment of human cardiovascular disease. PMID: 22163120
  96. Sonic hedgehog (Shh)-modified human CD34-positive cells protect against ventricular dilation and cardiac functional decline associated with experimental acute myocardial infarction. PMID: 22581926
  97. Mobilization of CD34+CXCR4+ cells in acute MI shows significant positive correlation with improvement of LVEF after 1 year PMID: 22547906
  98. Rates of expression of CD34 in osteosarcoma and osteochondroma were 96.7% and 16.7%respectively. In osteosarcoma, expression of endostatin was positively correlated with that of CD34. PMID: 22009965
  99. Osteopontin expression seems to be related to Ki-67 (proliferation index) and CD34 expression (angiogenesis marker) confirming its role in the pathogenesis of psoriasis. PMID: 22499302
  100. Increased levels of circulating SDF-1alpha and CD34+ CXCR4+ cells may play an important role in the vasculogenesis of moyamoya disease. PMID: 21435112

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Subcellular Location Membrane, Single-pass type I membrane protein
Protein Families CD34 family
Tissue Specificity Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.
Database Links

HGNC: 1662

OMIM: 142230

KEGG: hsa:947

STRING: 9606.ENSP00000310036

UniGene: Hs.374990

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