CD38 Monoclonal Antibody

Code CSB-MA785760
Size US$350
The deliverables will contain a corresponding secondary antibody if ordered this antibody. 
Image
  • IHC image of CSB-MA785760 diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-mouse IgG polymer labeled by HRP and visualized using 0.05% DAB.
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Product Details

Full Product Name Mouse anti-Homo sapiens (Human) CD38 Monoclonal antibody
Uniprot No. P28907
Target Names CD38
Alternative Names Acute lymphoblastic leukemia cells antigen CD38 antibody; ADP ribosyl cyclase 1 antibody; ADP ribosyl cyclase antibody; ADP ribosyl cyclase/cyclic ADP-ribose hydrolase antibody; ADP-ribosyl cyclase 1 antibody; ADPRC 1 antibody; ADPRC1 antibody; cADPr hydrolase 1 antibody; CD 38 antibody; CD38 antibody; CD38 antigen (p45) antibody; CD38 antigen antibody; CD38 molecule antibody; Cd38-rs1 antibody; CD38_HUMAN antibody; CD38H antibody; Cyclic ADP ribose hydrolase antibody; Cyclic ADP ribose hydrolase 1 antibody; Cyclic ADP-ribose hydrolase 1 antibody; EC 3.2.2.5 antibody; Ecto nicotinamide adenine dinucleotide glycohydrolase antibody; I-19 antibody; I19 (mouse) antibody; Lymphocyte differentiation antigen CD38 antibody; NAD(+) nucleosidase antibody; NIM-R5 antigen antibody; NIMR5 antigen (mouse) antibody; OTTHUMP00000158633 antibody; OTTHUMP00000217743 antibody; p45 antibody; T10 antibody
Raised in Mouse
Species Reactivity Human
Immunogen Synthesized peptide derived from human CD38
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Monoclonal
Isotype IgG1, Kappa
Purification Method The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Tested Applications ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
Gene References into Functions
  1. CD38 and cADPR are key players in the orches- tration of cellular responses to respiratory syncytial virus by infected monocyte-derived dendritic cells. PMID: 29178427
  2. our data are consistent with the conclusion that CD38 plays a role in murine and human lung tumorigenesis PMID: 29228209
  3. isatuximab decreases multiple myeloma cell- and bone marrow stromal cell-induced iTreg by inhibiting both cell-cell contact and TGFbeta/IL10. Finally, CD38 levels correlate with differential inhibition by isatuximab of Tregs from multiple myeloma versus normal donors.Targeting CD38 by isatuximab can preferentially block immunosuppressive Tregs and thereby restore immune effector function against multiple myeloma PMID: 28249894
  4. Empathic response mediates the CD38-altruism association. PMID: 28865941
  5. Increased levels of HLADR and CD38 expressions in peripheral blood were associated with oral lesions in HIV-positive patients. Periodontal disease was associated with HLADR expression. PMID: 28500735
  6. Panobinostat increased CD38 expression in a dose-dependent manner in primary myeloma cells. This was specific for myeloma cells and did not occur in lymphoma cell lines. This increase enabled the antimyeloma activity of daratumumab. PMID: 28476749
  7. To demonstrate the therapeutic effect of daratumumab in CLL, we generated a disseminated CLL mouse model with the CD38(+) MEC2 cell line and CLL patient-derived xenografts (CLL-PDX). Daratumumab significantly prolonged overall survival of MEC2 mice, completely eliminated cells from the infiltrated organs, and significantly reduced disease burden in the spleen of CLL-PDX PMID: 27637890
  8. CD38 mRNA levels were correlated with lower Autism Quotient (AQ), indicating enhanced social skills. CD38 expression and CD157 eQTL SNPs altogether account for a substantial 14% of the variance in sociality. the ecological validity of these findings was demonstrated with subjects with higher PBL CD38 expression having more friends, especially for males. PMID: 28212520
  9. CD38(lo) luminal cells are enriched in glands adjacent to inflammatory cells and exhibit epithelial nuclear factor kappaB (NF-kappaB) signaling. In response to oncogenic transformation, CD38(lo) luminal cells can initiate human prostate cancer in an in vivo tissue-regeneration assay PMID: 27926864
  10. Results provide evidence that CD38 enhanced the proliferation and inhibited the apoptosis of cervical cancer cells by affecting the mitochondria functions. PMID: 28544069
  11. these data demonstrate an important role for CD38 and complement-inhibitory protein expression levels in daratumumab sensitivity. PMID: 27307294
  12. Results may imply that CD38 expression either reflects or participates in pathogenic mechanisms of HIV disease independently of cell cycling. PMID: 27064238
  13. The data suggest that ZO-1, along with CD38 and Zap-70, plays a role in cell cycle regulation in chronic B cell leukemia, and may be used as a prognostic marker in the disease monitoring. PMID: 26306999
  14. Primary human melanoma cell lines suppress in vitro T cell proliferation through an adenosinergic pathway in which CD38 and CD73 play a prominent role. PMID: 26329660
  15. CD38 and its related genes are highly expressed in human nasopharyngeal carcinoma cell lines. PMID: 25630761
  16. soluble CD38 (sCD38) in seminal plasma increases the capacitation of sperm via specific interactions between sCD38 and the CD31 on the sperm. PMID: 26407101
  17. the expression of CD38+ on both CD4+, CD8+T lymphocytes from peripheral blood and CSF discriminated between viremic and non-viremic patients PMID: 26365593
  18. study points to an association between maternal SNPs in the CD38 in Japanese women and susceptibility to preterm birth. PMID: 26025338
  19. Peripheral blood CD38 bright CD8+ effector memory T cells predict acute graft-versus-host disease. PMID: 25881755
  20. CD38 is expressed on human MDSC-like cell population that is expanded in the peripheral blood of advanced-stage cancer patients. PMID: 26294209
  21. Upregulation of CD38 expression on multiple myeloma cells by all-trans retinoic acid improves the efficacy of daratumumab. PMID: 25975191
  22. Genetic variation in CD38 and breastfeeding experience interact to impact infants' attention to social eye cues. PMID: 26371313
  23. genetic polymorphism is associated with diffuse large B-cell lymphoma susceptibility in Egyptians PMID: 25564959
  24. Hairy-cell leukemia patients that were CD38-positive had a shorter mean time to salvage therapy than CD38-negative ones. CD38 expression in HCL drives poor prognosis by promoting survival and heterotypic adhesion. PMID: 26170397
  25. alterations in content of soluble molecules CD38 are associated with characteristics of tumor process that indicates at their monitoring significance under malignant neoplasms of uterus PMID: 26470437
  26. The results indicate that the net charge of the N-terminal segment is important in determining the membrane topology of CD38 and that the type III orientation can be a functional form of CD38 for Ca(2)-signaling. PMID: 25447548
  27. The majority of extranodal NK/T cell lymphoma cases were CD38 positive, which significantly correlated with poor outcomes. PMID: 25865943
  28. High levels of CD38 reduced intracellular (NAD+) levels and blocked acquired resistance by inhibiting the activity of the NAD+-dependent SIRT1 deacetylase PMID: 24967705
  29. CD38 status was associated with behavior and psychological reactions within live interactions, as well as global relationship quality PMID: 24396004
  30. These results validate CD38 as a therapeutic target and support the current evaluation of this unique CD38-targeting functional antibody in phase I clinical trials in patients with CD38+ B-cell malignancies. PMID: 24987056
  31. At the same time, CD38 overexpression affected the expression of PI3K, Akt, MDM2 and p53 in vivo PMID: 25310288
  32. CD38 expression is regulated by micro-RNA 708 in airway smooth muscle cells. PMID: 25175907
  33. CD38 has a role in chronic lymphocytic leukemia growth and trafficking PMID: 24990614
  34. Chronic lymphocytic leukemia cells express CD38 in response to Th1 cell-derived IFN-gamma by a T-bet-dependent mechanism. PMID: 25505279
  35. Increased numbers of circulating ICOS(+) and IL-21(+) Tfh and CD38(+) plasma cells may be exhibited by patients with recent diagnoses of primary biliary cirrhosis. PMID: 25404409
  36. nominal associations were found between autism spectrum disorder scores and single-nucleotide polymorphisms in OXT, ARNT2 and CD38 PMID: 24635660
  37. Autism and features of regression-previously acquired speech lost in the second year of life. The younger sister, who also had asthma, inherited a maternal deletion of 4p15.32 that results in a BST1-CD38 fusion transcript. PMID: 24634087
  38. results demonstrate that CD38(+) cells are a useful model to study effects of the cellular NAD levels on cellular processes and establish a new linker between cellular NAD levels and oxidative stress PMID: 24295520
  39. only one SNP in CD38 was significantly associated with social integration and that SNP predicted when using a dichotomized indicator of social connectedness, but not a continuous measure of social connectedness or the continuously married outcome. PMID: 24209975
  40. Data suggest that the uniquely increased expression of CD38 and E2F2 in rheumatoid arthritis (RA) synovial tissues contribute to the immunoactivation of the disease. PMID: 24397353
  41. PBMC from MM patients display a deregulated response related to CD38 activation pathway defects; CD38 may be functionally involved in the progression of this pathology via the secretion of high levels of IL-6 that protects neoplastic cells from apoptosis PMID: 24489445
  42. These data suggest that both functional roles of CD38 might be important in the pathogenesis of B-CLL. PMID: 24216102
  43. Atorvastatin and rosiglitazone did not affect the expression of CD38. PMID: 23686733
  44. Data suggest CD38 (CD38 antigen (p45) protein) and CD49d (alpha4 Integrin; very late antigen-4 alpha) are more than just markers of an aggressive chronic lymphocytic leukemia (CLL) cell type and play functional roles in pathobiology of CLL. [REVIEW] PMID: 24288111
  45. CD38 is expressed within caveolae and its function is linked to the caveolar regulatory proteins. PMID: 24275509
  46. Report diagnosis of multiple myeloma using two-color flow cytometry based on kappa/lambda ratios of CD38-gated plasma cells. PMID: 23755763
  47. CD38-cADPR mediates bile acid-induced pancreatitis and acinar cell injury through aberrant intracellular Ca(2+) signaling. PMID: 23940051
  48. The frequency of CD38high antibody-secreting cells (ASCs) is increased during the acute phase of hepatitis A virus (HAV) infection. Substantial numbers of ASCs are non-HAV-specific and dominantly secrete IgM. PMID: 23729443
  49. Data show that ADP-ribosylation of CtBP1-S/BARS by brefeldin A (BFA) occurs via synthesis of a BFA-ADP-ribose conjugate by the ADP-ribosyl cyclase CD38 and covalent binding of the BFA-ADP-ribose conjugate into the CtBP1-S/BARS NAD(+)-binding pocket. PMID: 23716697
  50. CD38 signals upregulate expression and functions of matrix metalloproteinase-9 in chronic lymphocytic leukemia cells. PMID: 22955446
  51. PECAM1+/CD38+ Vascular Cells can be Identified in Human Foreskin and in Vascular Sprouts of Basal Cell Carcinomas. PMID: 23308177
  52. Increase in the level of serum PECAM-1/CD31, a CD38 non-substrate ligand, is associated with endothelial dysfunction and correlates with elevated PECAM-1/CD31 levels and the number of CD38-positive lymphocytes in bronchial asthma patients. PMID: 23718062
  53. Identification of ADP-ribosylation sites of CD38 mutants by precursor ion scanning mass spectrometry. PMID: 23123429
  54. The detection of the cytoplasmic kappa/lambda ratio of CD38-gated CD138(+) plasma cells may be a useful tool in the diagnosis of plasma cell myeloma. PMID: 23021410
  55. Interleukin 22 is increased and correlated with CD38 expression in patients with B-chronic lymphocytic leukemia. PMID: 22909798
  56. The identification of these two forms of CD38 suggests that flipping the catalytic domain from the outside to the inside of the cell may be a mechanism regulating its signaling activity. PMID: 22969159
  57. Studies indicate that both cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) are generated by CD38/ADP-ribosyl cyclases. PMID: 22677461
  58. Data indicate the simultaneous analysis of CD64 together with CD304 (Neuropilin-1) or the combination of CD11b and CD38 was suitable for the identification of rheumatoid arthritis (RA)patients with high current activity in synovitis. PMID: 22251373
  59. in the tumor cells of patients with colorectal cancer the expression of the CD38 gene is heterogeneous. PMID: 23156678
  60. In human airway smooth muscle cells, regulation of CD38 expression occurs by specific class I PI3K isoforms. PMID: 22556157
  61. Reduced plasma oxytocin and both oxytocin receptor and CD38 risk alleles were related to less parental touch PMID: 22336563
  62. CD38 gene polymorphism is associated with chronic lymphocytic leukemia. PMID: 22721814
  63. miR-140-3p modulates CD38 expression in human airway smooth muscle cells through direct binding to the CD38 untranslated region and indirect mechanisms involving activation of p38 MAPK and NF-kappaB. PMID: 22773691
  64. This study provided evidence that rs3796863 of CD31 antigen impacts social processing on a very basic level. PMID: 22278094
  65. study contributes to understanding of the physiological functions of CD38 enzyme, by reporting its enzyme activity distribution in healthy individuals and demonstrating a significant positive correlation with age PMID: 22236458
  66. CD38 expression have independent prognostic value in early stage chronic lymphocytic leukaemia (CLL). PMID: 22171799
  67. Data show that in HIV-1-infected astrocytes, IL-1beta-induced increases in CD38 levels were regulated through the MAPK signaling pathway and by the transcription factor NF-kappaB. PMID: 22027397
  68. expression of CD38 antigen and ZAP-70 have an exceptional significance in the prediction of prognosis in CLL patients. PMID: 22338471
  69. Structure-function relationships have been analyzed to assess the structural determinants important for catalyis-based inhibitors of NAD glycohydrolase activity of CD38. PMID: 22142305
  70. We found a positive correlation between blood protein carbonyl groups with CD38 expression and a negative correlation with ZAP 70 expression PMID: 21945028
  71. Analysis of CD38 and ZAP70 mRNA expression among cytogenetic subgroups of Iranian chronic-lymphocytic-leukemia patients. PMID: 22002134
  72. NAADP hydrolysis depends, at least in part, on CD38 expression. CD38 is not necessary for NAADP production, but rather catalyses degradation of NAADP. PMID: 22020217
  73. These results suggest that CD38 plays a general role in oxytocin secretion PMID: 21893160
  74. The 184 locus G allele of CD38 may be protective against CML, and reduce the risk of CML relapse. PMID: 21518472
  75. These data argue for a prominent role of VLA-4 but not CD38 expression in the homing of chronic lymphocytic leukemia cells to bone marrow (BM) niches and in human BM infiltration. PMID: 21876768
  76. Data show that the genotype of a SNP (rs6449182; C>G variation) in the CpG island of intron 1, harboring the retinoic-acid response element, exerts differential roles in CD38 expression in ASD and in parental LBC. PMID: 21528155
  77. Data indicate that high iLR expression was strongly correlated with negativity for CD38 and ZAP-70 expression and mutated IGVH gene status. PMID: 21055809
  78. Synergistic TLR agonist stimulation in combination with IFN-alpha and IFN-gamma was the best method for regulating CD38 and CD74 expression PMID: 21423200
  79. The second decade of studies on CD38 in chronic lymphocytic leukemia will tell if the molecule is an effective target for antibody-mediated therapy in this currently incurable leukemia. PMID: 21765022
  80. When combined with clinical staging, the presence of a detectable CD38 antigen expression can be used to improve the identification of chronic lymphocytic leukemia patients with more aggressive disease. PMID: 20002855
  81. The determination of TK, ZAP-70 and CD38 together allows patients susceptible to a possible stage of the disease, to be identified. PMID: 21716207
  82. Data show there was no correlation between the MDR1 genotypes and Binet stage, unmutated immunoglobulin heavy-chain variable region (IGHV) status, CD38 expression, ZAP-70 expression, and p53 deletion. PMID: 21463115
  83. N-terminal of CD38 expressed on the cell surface functions as a receptor for an unknown ligand and triggers positive signals for insulin secretion PMID: 21387169
  84. CD38 expression by chronic lymphocytic leukemic cells was regulated not only by elements of the murine microenvironment but also by co-engrafting non-malignant human T cells PMID: 21692849
  85. gene mutational status and CD38 expression correlated with good Methylation PMID: 21051931
  86. CD38(+) lymphocytes represent abnormal mononuclear cell populations in atrophic oral lichen planus (OLP) lesions indicating forms of OLP might exist with different pathogenesis, despite similar histology and clinical behavior. PMID: 21237436
  87. Data show that neither a specific CD38 ectoenzyme inhibitor nor a point mutation that cripples enzymatic activity (CD38 E226Q) diminishes ATRA-induced differentiation or G1/0 arrest. PMID: 21156171
  88. CD38 upregulation was primarily conditioned by the presence of E2A and then by the G allele PMID: 21212793
  89. A focal point for probing a possible relationship between CD38, an important immune cell marker, and ASD is the link between autism and autoimmune diseases PMID: 21182206
  90. TNF-alpha regulation of CD38 expression in human airway smooth muscle: role of MAP kinases and NF-kappaB. PMID: 21153349
  91. mutation of a key residue at the active site, E146, inhibits the hydrolysis activity of CD38 but greatly increases its cyclization activity PMID: 21134381
  92. Data suggest that the differential induction of CD38 by TNF-alpha in ASMA cells is due to increased transcriptional regulation involving ERK and p38 MAPK activation and is independent of changes in NF-kappaB or AP-1 activation. PMID: 20693316
  93. analysis of human CD38's wild type, E226 and E146 mutants PMID: 20640790
  94. these data should provide an insight for elucidating the roles of CD38 in oxidative stresses and a novel perspective of dealing with the ischemia/reperfusion-related diseases. PMID: 20638362
  95. Our results call for functional and expression assay to assess the biological effects of the variant. Furthermore, the W140 allele could be a potential risk factor for a subset of Japanese autism spectrum disorder patients. PMID: 20435366
  96. Results suggests that the CD31/CD38 axis activates genetic programs relevant for proliferative responses. It also indicates a contribution of this pathway to the processes mediating migration and homing. PMID: 19956559
  97. CD38(+)CD8(+) T cells can be an appropriate immunological marker for early detection and antiviral therapeutic monitoring of human cytomegalovirus infection after orthotopic liver transplantation. PMID: 19817952
  98. Studies indicate that among the multitude of prognostic markers evaluated in CLL patients, IgVH mutational status, ZAP-70, and CD38 are some of the most frequently reported. PMID: 19679010
  99. Low CD38 expression parallels a lower propensity to apoptosis. In vivo CD38 crosslinking by its ligand may play a pivotal role in B-CLL apoptosis, and chlorambucil affects CD38 levels. PMID: 11836173
  100. CD38 plays a role in the progression of B-chronic lymphocytic leukemia and can be used as a prognostic marker PMID: 12368155

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Subcellular Location Membrane, Single-pass type II membrane protein
Protein Families ADP-ribosyl cyclase family
Tissue Specificity Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.
Database Links

HGNC: 1667

OMIM: 107270

KEGG: hsa:952

STRING: 9606.ENSP00000226279

UniGene: Hs.479214

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