AADAT Antibody, Biotin conjugated

Code CSB-PA843276LD01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) AADAT Polyclonal antibody
Uniprot No. Q8N5Z0
Target Names AADAT
Alternative Names 2 aminoadipate aminotransferase antibody; 2 aminoadipate transaminase antibody; 2-aminoadipate aminotransferase antibody; 2-aminoadipate transaminase antibody; Aadat antibody; AADAT_HUMAN antibody; Aadt antibody; AI875679 antibody; Alpha aminoadipate aminotransferase antibody; Alpha-aminoadipate aminotransferase antibody; Aminoadipate aminotransferase antibody; EC 2.6.1.39 antibody; EC 2.6.1.7 antibody; KAT/AadAT antibody; KAT2 antibody; KATII antibody; Kynurenine oxoglutarate transaminase 2 antibody; Kynurenine aminotransferase II antibody; Kynurenine oxoglutarate aminotransferase II antibody; Kynurenine oxoglutarate transaminase II antibody; Kynurenine--oxoglutarate aminotransferase II antibody; Kynurenine--oxoglutarate transaminase II antibody; Kynurenine/alpha-aminoadipate aminotransferase mitochondrial [Precursor] antibody; Kynurenine/alpha-aminoadipate aminotransferase; mitochondrial antibody; L kynurenine/alpha aminoadipate aminotransferase antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial protein (30-425AA)
Immunogen Species Homo sapiens (Human)
Conjugate Biotin
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).
Gene References into Functions
  1. Immunohistochemical analysis revealed the presence of KAT I, II, and III in all examined corneal sections. PMID: 28706436
  2. he optimised method of protein production provides a fast and reliable technique to generate large quantities of active human KAT2 suitable for future small-molecule lead compound screening and structural design work. PMID: 26773745
  3. Participants with major depression had lower levels of kynurenine compared to controls, with intermediate concentrations in somatoform patients. PMID: 24140252
  4. Somatization is characterized by disorders in kynurenine aminotransferase activity and an increased neurotoxic potential PMID: 21712776
  5. association of SNP AADAT+401C/T with the host immune response to bacterial meningitis, suggesting that this SNP may affect the host ability in recruitment of leukocytes to the infection site PMID: 21473761
  6. analysis of the crystal structure of kynurenine aminotransferase II PMID: 18056995
  7. analysis of the crystal structure of human kynurenine aminotransferase II PMID: 18056996
  8. A human cDNA encodes a 425-residue protein with a mitochondrial cleavage signal and a pyridoxal-phosphate binding site, ~70% identical to the mouse and rat AADAT orthologs. Bacterial expression studies confirm that the gene encodes AADAT activity. PMID: 12126930

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Subcellular Location Mitochondrion
Protein Families Class-I pyridoxal-phosphate-dependent aminotransferase family
Tissue Specificity Higher expression in the liver. Also found in heart, brain, kidney, pancreas, prostate, testis and ovary.
Database Links

HGNC: 17929

OMIM: 611754

KEGG: hsa:51166

STRING: 9606.ENSP00000226840

UniGene: Hs.529735

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