AAK1 Antibody, FITC conjugated

Datasheet
Code CSB-PA643571LC01HU
Size US$299

Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) AAK1 Polyclonal antibody
Uniprot No. Q2M2I8
Target Names AAK1
Alternative Names AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1), AAK1, KIAA1048
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human AP2-associated protein kinase 1 protein (274-465AA)
Immunogen Species Homo sapiens (Human)
Conjugate FITC
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Still Have Questions? Leave a Message or Start an on-line Chat

Target Data

Function Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.
Subcellular Location Cell membrane, Peripheral membrane protein, Membrane, clathrin-coated pit
Protein Families Protein kinase superfamily, Ser/Thr protein kinase family
Tissue Specificity Detected in brain, heart and liver. Isoform 1 is the predominant isoform in brain.
Database Links

HGNC: 19679

OMIM: 616405

KEGG: hsa:22848

STRING: 9606.ENSP00000386456

UniGene: Hs.468878

Most popular with customers

Newsletters

Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

Copyright © 2007-2018 www.cusabio.com CUSABIO TECHNOLOGY LLC All Rights Reserved.