CD47|Proteinase K|EGFR|BCMA|PD-L1|CD276|ACE2|TMPRSS2|Exosome Isolation Kits
Code | CSB-PA05264D0Rb |
Size | US$299 |
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Full Product Name | Rabbit anti-Homo sapiens (Human) AATF Polyclonal antibody |
Uniprot No. | Q9NY61 |
Target Names | AATF |
Alternative Names | AATF antibody; AATF_HUMAN antibody; Apoptosis antagonizing transcription factor antibody; Apoptosis-antagonizing transcription factor antibody; BFR2 antibody; CHE 1 antibody; CHE1 antibody; DED antibody; Protein AATF antibody; Rb binding protein Che 1 antibody; Rb-binding protein Che-1 antibody |
Raised in | Rabbit |
Species Reactivity | Human |
Immunogen | Recombinant Human Protein AATF protein (6-294AA) |
Immunogen Species | Homo sapiens (Human) |
Conjugate | Biotin |
Clonality | Polyclonal |
Isotype | IgG |
Purification Method | >95%, Protein G purified |
Concentration | It differs from different batches. Please contact us to confirm it. |
Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Form | Liquid |
Tested Applications | ELISA |
Protocols | ELISA Protocol |
Troubleshooting and FAQs | Antibody FAQs |
Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
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Function | May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. |
Gene References into Functions |
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Subcellular Location | Nucleus, nucleolus |
Protein Families | AATF family |
Tissue Specificity | Ubiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta and thymus. |
Database Links |
HGNC: 19235 OMIM: 608463 KEGG: hsa:26574 STRING: 9606.ENSP00000225402 UniGene: Hs.195740 |