AATF Antibody, HRP conjugated

Datasheet
Code CSB-PA05264B0Rb
Size US$299

Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) AATF Polyclonal antibody
Uniprot No. Q9NY61
Target Names AATF
Alternative Names Protein AATF (Apoptosis-antagonizing transcription factor) (Rb-binding protein Che-1), AATF, CHE1 DED
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Protein AATF protein (6-294AA)
Immunogen Species Homo sapiens (Human)
Conjugate HRP
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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Target Data

Function May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
Subcellular Location Nucleus, nucleolus
Protein Families AATF family
Tissue Specificity Ubiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta and thymus.
Database Links

HGNC: 19235

OMIM: 608463

KEGG: hsa:26574

STRING: 9606.ENSP00000225402

UniGene: Hs.195740

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