ABCG5 Antibody, HRP conjugated

Datasheet
Code CSB-PA863956LB01HU
Size US$299
Uniprot No. Q9H222
Protocols ELISA Protocol
Immunogen Recombinant Human ATP-binding cassette sub-family G member 5 protein (1-127AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.
Form Liquid
Conjugate HRP
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias ATP-binding cassette sub-family G member 5 (Sterolin-1), ABCG5
Immunogen Species Homo sapiens (Human)
Research Area Cardiovascular
Target Names ABCG5
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane
Involvement in disease Sitosterolemia (STSL)
Subcellular Location Cell membrane, Multi-pass membrane protein, Apical cell membrane, Multi-pass membrane protein
Protein Families ABC transporter superfamily, ABCG family, Eye pigment precursor importer (TC 3.A.1.204) subfamily
Tissue Specificity Strongly expressed in the liver, lower levels in the small intestine and colon.
Database Links

HGNC: 13886

OMIM: 210250

KEGG: hsa:64240

STRING: 9606.ENSP00000260645

UniGene: Hs.132992

Pathway Cholesterol metabolism

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