ABHD2 Antibody, Biotin conjugated

Code CSB-PA001094LD01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) ABHD2 Polyclonal antibody
Uniprot No. P08910
Target Names ABHD2
Alternative Names ABHD2 antibody; LABH2Monoacylglycerol lipase ABHD2 antibody; EC 3.1.1.23 antibody; 2-arachidonoylglycerol hydrolase antibody; Abhydrolase domain-containing protein 2 antibody; Acetylesterase antibody; EC 3.1.1.6 antibody; Lung alpha/beta hydrolase 2 antibody; Progesterone-sensitive lipase antibody; EC 3.1.1.79 antibody; Protein PHPS1-2 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Monoacylglycerol lipase ABHD2 protein (31-320AA)
Immunogen Species Homo sapiens (Human)
Conjugate Biotin
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane
Gene References into Functions
  1. Suppression of ABHD2 in OVCA420 cells increased phosphorylated p38 and ERK, platinum resistance, and side population cells (p<0.01, respectively). Conversely, overexpression of ABHD2 decreased resistance to anoikis (p<0.05) and the amount of phosphorylated p38 and ERK in OVCA420 and SKOV3 cells. PMID: 27323405
  2. A mutant ABHD2 developed with alanine in place of Ser(207). PMID: 27247428
  3. These results show that joint tests of main effects and gene-gene interaction reveal associations at some novel loci that were missed when considering main effects alone. PMID: 28813576
  4. ABHD2 gene single nucleotide polymorphisms, such as rs12442260 contribute to chronic obstructive pulmonary disease susceptibility in the Chinese Han population. PMID: 25880496
  5. ABHD2 is highly expressed in spermatozoa, binds progesterone, and acts as a progesterone-dependent lipid hydrolase by depleting the endocannabinoid 2-arachidonoylglycerol (2AG) from plasma membrane. PMID: 26989199
  6. Patients with selective immunoglobulin (Ig)A deficiency have a highly significant increase of homozygousity of HS1.2 allele *1, with an increase of 2.6-fold; the HS1.2 polymorphism influences Ig seric production, but not IgG switch. PMID: 20007591
  7. Our results showed that the ABHD2 was expressed in atherosclerotic lesions, and that the ABHD2 expression was significantly higher in the patients with UA than with SA. PMID: 17980156

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Subcellular Location Cell projection, cilium, flagellum membrane, Single-pass type II membrane protein, Cell membrane, Single-pass type II membrane protein
Protein Families AB hydrolase superfamily, AB hydrolase 4 family
Tissue Specificity Present in sperm (at protein level).
Database Links

HGNC: 18717

OMIM: 612196

KEGG: hsa:11057

STRING: 9606.ENSP00000268129

UniGene: Hs.122337

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