ADGRE2 Antibody, FITC conjugated

Datasheet
Code CSB-PA887050LC01HU
Size US$299
Uniprot No. Q9UHX3
Protocols ELISA Protocol
Immunogen Recombinant Human Adhesion G protein-coupled receptor E2 protein (151-323AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Is a regulator of mast cell degranulation (PubMed:26841242).
Form Liquid
Conjugate FITC
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Adhesion G protein-coupled receptor E2 (EGF-like module receptor 2) (EGF-like module-containing mucin-like hormone receptor-like 2) (CD antigen CD312), ADGRE2, EMR2
Immunogen Species Homo sapiens (Human)
Research Area Signal Transduction
Target Names ADGRE2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Still Have Questions? Leave a Message or Start an on-line Chat
Function Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Is a regulator of mast cell degranulation
Involvement in disease Vibratory urticaria (VBU)
Subcellular Location Cell membrane, Multi-pass membrane protein, Cell projection, ruffle membrane, Multi-pass membrane protein
Protein Families G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily
Tissue Specificity Expression is restricted to myeloid cells. Highest expression was found in peripheral blood leukocytes, followed by spleen and lymph nodes, with intermediate to low levels in thymus, bone marrow, fetal liver, placenta, and lung, and no expression in heart
Database Links

HGNC: 3337

OMIM: 125630

KEGG: hsa:30817

STRING: 9606.ENSP00000472280

UniGene: Hs.531619

Related Products

ADGRE2 Antibodies

ADGRE2 Antibodies for Homo sapiens (Human)

ADGRE2 Antibodies for Human

ADGRE2 Proteins

ADGRE2 Proteins for Homo sapiens (Human)

Most popular with customers

Newsletters

Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

Copyright © 2007-2018 www.cusabio.com CUSABIO TECHNOLOGY LLC All Rights Reserved.