AGT Antibody, Biotin conjugated

Code CSB-PA001463ED01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) AGT Polyclonal antibody
Uniprot No. P01019
Target Names AGT
Alternative Names Aangiotensinogen (serpin peptidase inhibitor clade A member 8) antibody; AGT antibody; AI265500 antibody; Alpha 1 antiproteinase antitrypsin antibody; Ang antibody; Ang I antibody; Ang II antibody; Ang III antibody; AngII antibody; Angiotensin I antibody; Angiotensin II antibody; Angiotensin III antibody; Angiotensin-3 antibody; Angiotensinogen (PAT) antibody; Angiotensinogen antibody; ANGT_HUMAN antibody; ANHU antibody; ANRT antibody; AT-2 antibody; AT-II antibody; Des-Asp[1]-angiotensin II antibody; FLJ92595 antibody; FLJ97926 antibody; MGC105326 antibody; PAT antibody; Pre angiotensinogen antibody; Serine (or cysteine) proteinase inhibitor antibody; Serpin A8 antibody; Serpin peptidase inhibitor clade A member 8 antibody; SERPINA8 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Angiotensinogen protein (35-285AA)
Immunogen Species Homo sapiens (Human)
Conjugate Biotin
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.; FUNCTION
Gene References into Functions
  1. Patients with heart failure and type 2 diabetes mellitus with AGT TT + MT genotype had a higher level of ST2 and a higher probability of unfavorable cardiovascular events during 24 months of observation compared with MM genotype carriers. PMID: 29578435
  2. Unfavorable genotype of polymorphic variants of candidate gene participating in endothelial dysfunction AGT (Thrl74Met and Met23SThr) was associated with changes in levels of their active substances in individuals exposed to mercury. PMID: 30351652
  3. Angiotensin 1-7 can modulate cell adhesion and epithelial-mesenchymal transition of normal prostate epithelial cells. PMID: 29802847
  4. These findings reveal the critical role of hypoxia in producing local angiotensin II by a lactate-chymase-dependent mechanism and highlight the importance of local angiotensin II in regulating radioresistance of hypoxic tumor cells. PMID: 28205588
  5. The reduced urinary AGT/creatinine in Autralian Indigenous pregnant women may reflect subclinical renal dysfunction which limits the ability of the kidney to maintain sodium balance and could indicate an increased risk of pregnancy complications and/or future renal disease. PMID: 29674190
  6. ACE2 and other enzymes can form ANG-(1-7) directly or indirectly from either the decapeptide ANG I or from ANG II. [review] PMID: 29351514
  7. The ACE and AGT gene polymorphisms are not associated with the progress of diabetes developing into retinopathy in Chinese patients with type 2 diabetes. PMID: 29378484
  8. AGT M235T and T174M variants contribute to an increased risk of developing preeclampsia (PE), and for M235T to PE severity. PMID: 29366364
  9. Data, including data using network analysis, suggest that angiotensinogen (AGT), mitogen-activated protein kinase-14 (MAPK14), and prothrombin (F2) in placental villous tissues are core factors in early embryonic development; these studies involved proteomics and bioinformatics analysis of altered protein expression in placental villous tissue from early recurrent miscarriage patients in comparison to control tissues. PMID: 29277264
  10. The AGT (M235T) gene polymorphism do not seem to have a significant effect on the development of clinical properties or cardiovascular comordities of acromegalic patients. PMID: 28712073
  11. Angiotensin II has a role in increasing glomerular permeability by beta-arrestin mediated nephrin endocytosis PMID: 28004760
  12. After donor nephrectomy, increasing uAGT levels can be the result of activation of the intrarenal renin-angiotensin system affecting the compensatory changes in the remaining kidney. PMID: 28988519
  13. M235T polymorphism of the AGT gene seems unrelated to the development or the clinical course of endometriosis. PMID: 29303211
  14. AGT missense polymorphisms are not associated with diabetic nephropathy in our subset of Slovenian type 2 diabetes mellitus patients PMID: 28488548
  15. Association of AGT single nucleotide polymorphism rs3789678 and gestational hypertension in Chinese population. PMID: 27910864
  16. Data suggest that angiotensin-II plays important role in development of albuminuria, particularly in subjects with impaired glucose metabolism; here, serum angiotensin-II levels are up-regulated in subjects with prediabetes and type 2 diabetes as compared to subjects with normal glucose metabolism; elevated serum angiotensin-II level may be early biomarker or risk factor for vasculitis. PMID: 28797632
  17. The T allele of AGT may play a role in the pathogenesis of preeclampsia in South African Black women. PMID: 28641212
  18. These data indicate that Ang II-AT2R regulates human bone marrow MSC migration by signaling through the FAK and RhoA/Cdc42 pathways. PMID: 28697804
  19. Data suggest that up-regulaton of Ang-(1-7) levels in follicular fluid correlates with increases in number of mature oocytes retrieved upon ovarian stimulation in preparation for in vitro fertilization. PMID: 28402544
  20. Urinary angiotensinogen and renin excretion are elevated in CKD patients. Both parameters are negatively associated with eGFR and these associations are independent of urinary albumin excretion PMID: 28395289
  21. Reduced IL-18 serum concentration in children after HUS with no difference in its urine concentration may indicate a loss of the protective effects of this cytokine on renal function due to previously occurred HUS. PMID: 27982687
  22. Angiotensin II initiates hepatocyte epithelial-mesenchymal transition by activating the NOX-derived H2O2-mediated NLRP3 inflammasome/IL-1ss/Smad circuit. PMID: 27445100
  23. angiotensin II induced abdominal aortic aneurysm growth and inflammation is attenuated by imatinib PMID: 27085160
  24. present study has demonstrated, for the first time, that high glucose augments AGT in human RPTCs through HNF-5, which provides a potential therapeutic target for diabetic nephropathy PMID: 29053707
  25. AngII-dependent phosphorylation of LCP1 in cultured podocytes was mediated by the kinases ERK, p90 ribosomal S6 kinase, PKA, or PKC. LCP1 phosphorylation increased filopodia formation. PMID: 28768720
  26. Autosomal dominant polycystic kidney disease (ADPKD), uniquely increases urinary angiotensinogen and renin excretion despite their circulating levels being comparable with those in non-ADPKD chronic kidney disease. PMID: 28747358
  27. Quaternary interactions and supercoiling modulate the cooperative DNA binding of AGT. PMID: 28575445
  28. results show that SNPs in the Hap-I of the hAGT gene promote high-fat diet-induced binding of transcription factors GR, CEBP-beta and STAT3, which lead to elevated expression of the hAGT gene in hepatic and adipose tissues PMID: 28467442
  29. Angiotensinogen import and subsequent trafficking to the mitochondria occurs in proximal kidney tubules. PMID: 27903492
  30. Transgenic mice expressing human AGT in the subfornical organ AGT and possibly ANG I/ANG II into the cerebral ventricles. PMID: 28490451
  31. AngII could induce pulmonary injury by triggering endothelial barrier injury, and such process may be related to the dephosphorylation of Y685-VE-cadherin and the endothelial skeletal rearrangement PMID: 28119542
  32. Renin-angiotensin system transgenic mouse model suggests that renal injury in preeclampsia may be mediated through local VEGF. PMID: 27927648
  33. endoplasmic reticulum stress induces apoptosis in human alveolar epithelial cells through mediation of unfolded protein response pathways, which in turn regulate the autocrine ANGII/ANG1-7 system. PMID: 27638906
  34. Angiotensin II stimulates PYY secretion, in turn inhibiting epithelial anion fluxes, thereby reducing net fluid secretion into the colonic lumen. PMID: 27447725
  35. NOXs had two time-dependent reactions in response to Ang II stimulation via MAPK pathwa PMID: 27807688
  36. increased Ang-II/Ang-(1-7) ratios may lead to Ang-II over-activation and aggravate atherosclerosis progression. PMID: 27432541
  37. urinary angiotensinogen could be a prognostic marker of the albuminuria reduction effects of olmesartan in patients with metabolic syndrome PMID: 27801805
  38. AGT expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
  39. Urinary angiotensinogen reflects intrarenal RAS status, and is of value to assess the severity of acute tubular necrosis . PMID: 27788506
  40. Data suggest that enhanced survival of normal prostate epithelial cells (PNT1A cell line) in presence of either or both angiotensin II (Ang II) and relaxin 2 (RLN2) appears to be associated with increased ratio of BCL2/BAX messenger RNA expression; thus, Ang II and/or RLN2 appear to be involved in regulation of apoptosis in prostate epithelium. PMID: 27119161
  41. increasing the serum levels of AngII increased the risk of acute myocardial infarction (AMI); the risk of AMI increased when the serum levels of AngII and KLK1 simultaneously increased; individuals with the combined genotypes of ACE DD and KLK1 GG showed increased risk of AMI compared with those with the combined genotypes of ACE II and KLK1 AA PMID: 27329205
  42. genetic association study and meta-analysis revealed a significant association between M235T polymorphism of angiotensinogen and myocardial infarction risk PMID: 27586550
  43. significant association between Thr207Met polymorphism and chronic kidney disease progression in autosomal dominant polycystic kidney disease PMID: 26482465
  44. The aim of this work is to assess the influence of the rs1799752 polymorphism of the angiotensin-converting enzyme (ACE) gene and the rs699 polymorphism of the angiotensinogen (AGT) gene on the in-stent restenosis in Polish patients with stable coronary artery disease. PMID: 27162064
  45. in cultured H9C2 cells and that CyPA/CD147 signaling pathway inhibition protects against Ang II-induced cardiomyocyte hypertrophy. PMID: 27590243
  46. The circulating ACE2 and Ang-(1-7) levels were related to neither rs4646155 nor rs879922 in female or male patients.In conclusion, the rs2106809 polymorphism of the ACE2 gene may be a determinant of the circulating Ang-(1-7) level in female patients with hypertension, suggesting a genetic association between circulating Ang-(1-7) levels and ACE2 gene polymorphisms in patients with hypertension. PMID: 27310975
  47. observed significantly higher prevalence of ACE DD and AGTR1 1166CC genotypes in hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) patients. Also, 235TT genotype of AGT (M235T) was significantly associated with enhanced risk of the disease phenotype in HCM, DCM, and RCM. PMID: 28120210
  48. Angiotensinogen expression is down regulated in human ileal Crohn's disease, particularly in the presence of inflammation and current cigarette smoking, implicating the mesenteric vasculature and mucosal hypoxia as co-factors in ileal CD pathogenesis. PMID: 27014752
  49. AGT M235T polymorphism was associated with SAH risk in Caucasian-Brazilians, and no association was detected with CAD PMID: 27019433
  50. Protective role of g.5855G>A polymorphism in the development of Essential Hypertension in Indian population was reported. The results reflect possibility of ethnic variation in contribution of g.5855G>A polymorphism of the AGT gene to the disease. PMID: 27398822
  51. Urinary TGF-beta1 and ET-1 levels were associated with AGT level, which likely reflects an early interplay between tissue remodeling and RAAS in obesity-related kidney injury. PMID: 26482255
  52. results of this meta-analysis suggested that the AGT A-20C polymorphism was associated with risk of essential hypertension in Asians PMID: 26505451
  53. Ang II induces cardiac fibrosis by enhancing DDR2 expression in cardiac fibroblasts via p38 MAPK-mediated activation of NF-kappaB. PMID: 26772530
  54. Polymorphisms of three genes (ACE, AGT and CYP11B2) in the renin-angiotensin-aldosterone system are not associated with blood pressure salt sensitivity. (Meta-analysis) PMID: 26556555
  55. There was an association between the AGT rs699 polymorphism and diabetes mellitus type 2 in the Brazilian patients. PMID: 26782563
  56. Results indicate that urinary angiotensinogen was associated with blood pressure elevation in this population of obese young adults. PMID: 26825581
  57. our analysis revealed that the associations of the AGT variants with T2DM were independently associated. PMID: 26682227
  58. The M allele of M235T might be associated with an increased risk of atrial fibrillation recurrence after catheter ablation. PMID: 26240116
  59. The urinary angiotensinogen level correlates with the overall maturity of renal function during the early postnatal period in critically ill neonates. PMID: 26116142
  60. the association of polymorphisms in angiotensinogen (AGT) and angiotensin II type 1 receptor (AGTR1), with blood lead levels and lead-related blood pressure in lead-exposed male workers in Korea, was investigated. PMID: 25031294
  61. the AGT polymorphisms have played a vital role in determining an individual's susceptibility to essential hypertension. PMID: 26391364
  62. There were significant differences in genotype and allele distributions of ACE gene rs4343 (pgentoype = 0.002 and pallele < 0.001) and AGTR1 gene rs5186 polymorphisms. PMID: 25077884
  63. rs699 in the AGT gene and rs5186 in the ATR1 gene were not associated with the risk and clinical outcomes of IgAN. PMID: 26588355
  64. The threonine variant of AGT M268T is a significant risk factor for abnormalities in specific white matter tracts and cognitive domains in healthy older adults. PMID: 26318936
  65. Increased plasma renin, AT and VEGF might play a role in the onset or development of superficial infantile hemangiomas. PMID: 26489635
  66. Blood pressure was significantly lower in angiotensinogen knock-out mice compared to controls fed a normal or high sodium diet. PMID: 26755736
  67. Detection of hANG(1-12) in hearts of homozygous transgenic rats expressing the hAGT gene suggests existence of non-renin-dependent enzyme mechanism capable of cleavage of human substrate. PMID: 26873967
  68. AGT-H1 haplotype was identified as protective Factor for Essential Hypertension in Kazakhs in Xinjiang. PMID: 26305278
  69. angiotensin-(1-7) plays a role in metabolic pathways related to cell death and cell survival in human endothelial cells PMID: 26388433
  70. dominance of the aminopeptidase A/Ang (2-10) and aminopeptidase A/Ang III (2-8) pathways in the metabolism of Ang I (1-10) and Ang II (1-8) over the ACE2/Ang (1-7) axis PMID: 25968123
  71. The ACE2-Ang (1-7)-Mas axis serves as an important signal pathway in endothelial cell protection in diabetic human arteries. PMID: 25867182
  72. Urinary AGT could be a prognostic marker of renoprotective effects of alogliptin in patients with T2D PMID: 26380312
  73. Hypertensive patients in this setting have predominantly low angiotensin II hypertension as a result of high salt intake. PMID: 26486596
  74. urinary AGT/protein ratio represents a novel specific marker of podocyte injury PMID: 26632605
  75. The current meta-analysis suggested that the M235T polymorphism in the angiotensinogen gene might be related to the increased risk of atrial fibrillation in Asians. PMID: 25172907
  76. The meta-analysis indicated the significant association of AGT gene polymorphisms (M235T, T174M) with risk of ischemic stroke in the Chinese population. PMID: 25944852
  77. the AGT gene was screened to detect already reported and novel variations contributing to the development of hypertension. PMID: 24452034
  78. These results indicate that Ang-II induces cardiac fibroblast proliferation and migration in part via Nox4/ROS-dependent IL-18 induction and MMP9 activation, and may involve AT1/Nox4 physical association. PMID: 26445208
  79. The AGT polymorphism did not modify the onset of strokes or migraine in our CADASIL sample PMID: 25819272
  80. Urinary AGT is an effective marker for predicting the progression of chronic renal impairment in preterm VLBW infants after their growth. PMID: 24178957
  81. Aliskiren prevents renal disease progression by suppressing both angiotensin I and II in human renin angiotensinogen transgenic mice with high salt loading. PMID: 24154707
  82. This meta-analysis confirms that the AGT G-217A gene polymorphism is associated with essential hypertension susceptibility. PMID: 26125750
  83. the augmented AGT released from apoptotic endothelial cells acts as a vital progenitor of Ang II to accelerate vascular remodelling PMID: 26147666
  84. The T174M polymorphism in the AGT gene may be related to an increased risk of myocardial infarction. PMID: 25966146
  85. AngII stimulates fibroblast migration and contraction through AT1 receptor, ALK5, and JNK. PMID: 25345602
  86. Urinary AGT was associated with ore advance CKD and hypertension in ADPKD patients. AGT was expressed in renal tubular epithelium and cyst lining epithelial cells. PMID: 26092580
  87. The present meta-analysis demonstrated that AGT M235T variant was not associated with risk of all cancer or various cancers. PMID: 23846033
  88. These findings show a relationship between the AGT-TT genotype and hypertension in patients with both hypertension and simple renal cysts. PMID: 23907112
  89. ACE2 and Ang-(1-7) significantly inhibit early atherosclerotic lesion formation via protection of endothelial function and inhibition of inflammatory response. PMID: 25721616
  90. AGT, ACE, and AT 1 R genes have overall effects with susceptibility to hypertension, where the SNPs of ACE have a mainly hypertension-associated effect and show an interacting effect to SNPs of AGT and AT 1 R genes PMID: 25961019
  91. Refractory hyperaldosteronism in heart failure is associated with plasma renin activity and angiotensinogen polymorphism. PMID: 25036270
  92. data indicate that FPPS may play an important role in Ang II-induced fibrotic responses in VSMCs PMID: 25847782
  93. Urinary angiotensinogen is a useful marker of intrarenal renin angiotension system activation pediatric IgA nephropathy patients. PMID: 25523477
  94. This review investigates recent data concerning the effects of Ang II on NVC with the intent of exploring new treatment perspectives for neurodegenerative diseases such as AD PMID: 25660297
  95. Leu84Phe and Ile143Val polymorphisms may be useful biomarkers for lung cancer in some specific populations. [review] PMID: 26376373
  96. We conclude that heterozygous substitutions at AGT and REN loci correlate significantly with end-stage renal disease in a north Indian population PMID: 25660845
  97. the AGT M235T polymorphism is a low-penetrant risk factor for the development of heart failure among Asians (Meta-Analysis) PMID: 24572548
  98. AGT and AGTR1 gene-gene interactions as part of the genetic architecture of congenital nephron number PMID: 26142106
  99. the T allele polymorphism in AGT gene may be considered as genetic risk factor for the development of nephropathy in diabetes PMID: 24737640
  100. he current meta-analysis suggests that agt polymorphism might be associated with increased risk of heart failure in Caucasians--{REVIEW} PMID: 23154270

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Involvement in disease Essential hypertension (EHT); Renal tubular dysgenesis (RTD)
Subcellular Location Secreted
Protein Families Serpin family
Tissue Specificity Expressed by the liver and secreted in plasma.
Database Links

HGNC: 333

OMIM: 106150

KEGG: hsa:183

STRING: 9606.ENSP00000355627

UniGene: Hs.19383

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