AKTIP Antibody, HRP conjugated

Code CSB-PA862043LB01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) AKTIP Polyclonal antibody
Uniprot No. Q9H8T0
Target Names AKTIP
Alternative Names AKT interacting protein antibody; AKT-interacting protein antibody; AKTIP antibody; AKTIP_HUMAN antibody; FT 1 antibody; FT1 antibody; Fused toes homolog antibody; Fused toes protein homolog antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human AKT-interacting protein (1-292AA)
Immunogen Species Homo sapiens (Human)
Conjugate HRP
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.
Gene References into Functions
  1. Results show that AKTIP co-purifies with A- and B-type lamins and partially co-localizes with lamins in interphase nuclei. In addition, AKTIP depletion lowers lamin A expression and induces senescence hallmarks including telomere homeostasis in human primary fibroblasts. PMID: 27512140
  2. results suggest that AKT1, FTO, and AKTIP polymorphisms were not associated with obesity/overweight in Brazilians children. PMID: 27342216
  3. FTS is involved in EGFR-mediated repair of DNA damage induced by cisplatin in ME180 cells PMID: 27535835
  4. AKTIP interacts with telomeric DNA and is required for telomere maintenance. PMID: 26110528
  5. High fused toes homolog expression is associated with radioresistance in cervical cancer. PMID: 25151576
  6. FTS silencing reduced EMT and cell migration by EGF treatment. These results demonstrate a novel function for FTS in EGF-mediated EMT process. PMID: 24971934
  7. *AKTIP single nucleotide polymorphisms are not associated with late-onset depression patients compared to healthy elderly controls. PMID: 24022875
  8. Targeted inhibition of FTS led to the shutdown of key elemental characteristics of cervical cancer and could lead to an effective therapeutic strategy. PMID: 21424602
  9. These data unraveled the involvement of new oncoprotein FTS in cervical cancer which plays a central role in carcinogenesis. PMID: 20945372
  10. Demographic and clinical characteristics and AKT1 single markers and haplotypes, but not AKTIP polymorphisms or interactions between AKT1 and AKTIP, are associated with increased risk for suicidal behavior in bipolar patients. PMID: 20132317
  11. Ft1 protein interacts directly with PKB, enhancing the phosphorylation of both of its regulatory sites by promoting its interaction with the upstream kinase PDK1 PMID: 14749367
  12. These data suggest that the FTS/Hook/FHIP complex functions to promote vesicle trafficking and/or fusion via the homotypic vacuolar protein sorting complex. PMID: 18799622

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Subcellular Location Cytoplasm, Cell membrane, Peripheral membrane protein
Protein Families Ubiquitin-conjugating enzyme family, FTS subfamily
Database Links

HGNC: 16710

OMIM: 608483

KEGG: hsa:64400

STRING: 9606.ENSP00000378152

UniGene: Hs.380897

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