APPL2 Antibody, FITC conjugated

Datasheet
Code CSB-PA818777LC01HU
Size US$299
Uniprot No. Q8NEU8
Protocols ELISA Protocol
Immunogen Recombinant Human DCC-interacting protein 13-beta protein (399-512AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction.
Form Liquid
Conjugate FITC
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias DCC-interacting protein 13-beta (Dip13-beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2), APPL2, DIP13B
Immunogen Species Homo sapiens (Human)
Research Area Signal Transduction
Target Names APPL2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction.
Involvement in disease A chromosomal aberration involving APPL2/DIP13B is found in patients with chromosome 22q13.3 deletion syndrome. Translocation t(12;22)(q24.1;q13.3) with SHANK3/PSAP2 (PubMed:11431708).
Subcellular Location Early endosome membrane, Peripheral membrane protein, Nucleus
Tissue Specificity High levels in brain, heart, kidney and skeletal muscle.
Database Links

HGNC: 18242

OMIM: 606231

KEGG: hsa:55198

STRING: 9606.ENSP00000258530

UniGene: Hs.506603

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