ATG14 Antibody, HRP conjugated

Datasheet
Code CSB-PA741052LB01HU
Size US$299
Uniprot No. Q6ZNE5
Immunogen Recombinant Human Beclin 1-associated autophagy-related key regulator protein (1-492AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (PubMed:18843052, PubMed:19050071). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (PubMed:20713597). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (PubMed:23878393). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (PubMed:25686604). Modulates the hepatic lipid metabolism (By similarity).
Form Liquid
Conjugate HRP
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Beclin 1-associated autophagy-related key regulator (Barkor) (Autophagy-related protein 14-like protein) (Atg14L), ATG14, ATG14L KIAA0831
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Research Area Signal Transduction
Target Names ATG14
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1
Subcellular Location Cytoplasm, Endoplasmic reticulum membrane, Peripheral membrane protein, Preautophagosomal structure membrane, Peripheral membrane protein, Cytoplasmic vesicle, autophagosome membrane, Peripheral membrane protein
Protein Families ATG14 family
Database Links

HGNC: 19962

OMIM: 613515

KEGG: hsa:22863

STRING: 9606.ENSP00000247178

UniGene: Hs.414809

Pathway Autophagy

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