ATG7 Antibody, FITC conjugated

Datasheet
Code CSB-PA002294LC01HU
Size US$299
Uniprot No. O95352
Immunogen Recombinant Human Ubiquitin-like modifier-activating enzyme ATG7 protein (386-676AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.
Form Liquid
Conjugate FITC
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Ubiquitin-like modifier-activating enzyme ATG7 (ATG12-activating enzyme E1 ATG7) (Autophagy-related protein 7) (APG7-like) (hAGP7) (Ubiquitin-activating enzyme E1-like protein), ATG7, APG7L
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Research Area Cell Biology
Target Names ATG7
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.
Subcellular Location Cytoplasm, Preautophagosomal structure
Protein Families ATG7 family
Tissue Specificity Widely expressed, especially in kidney, liver, lymph nodes and bone marrow.
Database Links

HGNC: 16935

OMIM: 608760

KEGG: hsa:10533

STRING: 9606.ENSP00000346437

UniGene: Hs.38032

Pathway Autophagy

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