AXIN1 Antibody, Biotin conjugated

Code CSB-PA517675LD01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) AXIN1 Polyclonal antibody
Uniprot No. O15169
Target Names AXIN1
Alternative Names AI316800 antibody; AXIN antibody; Axin 1 antibody; Axin-1 antibody; axin1 antibody; AXIN1_HUMAN antibody; Axis inhibition protein 1 antibody; Axis Inhibitor 1 antibody; Fu antibody; fused antibody; Fused; mouse; homolog of antibody; hAxin antibody; Kb antibody; Ki antibody; kinky antibody; knobbly antibody; MGC132911 antibody; MGC52315 antibody; PPP1R49 antibody; Protein Fused antibody; Protein phosphatase 1 regulatory subunit 49 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Axin-1 protein (418-707AA)
Immunogen Species Homo sapiens (Human)
Conjugate Biotin
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling
Gene References into Functions
  1. RNF146 exerted oncogenic role through ubiquitination of Axin1 to activate beta-catenin signaling. PMID: 29932918
  2. TRIM65 exerted oncogenic activities via ubiquitylation of Axin1 to activate the beta-catenin signaling pathway. PMID: 28754688
  3. coexpression of APC5 and Axin genes significantly downregulated Wnt signaling in human SW480 CRC cells and inhibited cell growth. PMID: 28731177
  4. data delineate opposing roles for gamma-Pcdh isoforms in regulating Wnt signalling and identify Axin1 as a novel protein interactor of the widely-expressed gamma-Pcdh-C3 isoform PMID: 27530555
  5. Genetic association of polymorphisms in AXIN1 gene with clear cell renal cell carcinoma in a Chinese population. PMID: 29053018
  6. Colorectal cancer cell lines identified VACO6 cells as a carrier of a canonical PTPRK(e1)-RSPO3(e2) fusion; cell line displayed marked in vitro and in vivo sensitivity to WNT blockade by the porcupine inhibitor LGK974. Long-term treatment of VACO6 cells with LGK974 led to the emergence of a resistant population carrying two frameshift deletions of the WNT pathway inhibitor AXIN1, with consequent protein loss. PMID: 28100566
  7. role in the formation of degradasomes and degradation of beta-catenin induced by the TNKSi G007-LK in colorectal cancer cells PMID: 28107521
  8. RUNX1 and AXIN1 proteins are strongly correlated in ER(-) tumors as well. PMID: 28055379
  9. Mutagenesis and binding studies using the bivalent TNKS binding domain of Axin1 demonstrate that only certain ankyrin repeat clusters combinations function together. SAXS analysis is consistent with a dynamic ensemble of TNKS ankyrin repeat conformations modulated by Axin1 interaction. PMID: 27594684
  10. LGALS3 and AXIN1 genes affect tumor sizes and the mucinous component via Wnt/ beta-catenin pathway in the pathogenesis of colorectal cancer PMID: 26894286
  11. The AXIN1 rs1805105 SNP was associated with small tumor size and early tumor stage in hepatocellular carcinoma. PMID: 26968103
  12. AXIN1 is expressed in meningioma along with APC and E-cadherin PMID: 27630299
  13. Data show that poly(ADP-ribose) polymerase (PARP) enzyme Tankyrase (TNKS) inhibition in colon cancer cells decreases beta-catenin signaling at the level of both Axin and APC2. PMID: 27068743
  14. Cancer point mutations in the scaffold protein Axin derail Wnt signaling and promote tumor growth in vivo through a gain-of-function mechanism. PMID: 26974125
  15. The pool of ADP-ribosylated Axin, which is degraded under basal conditions, increases immediately following Wnt stimulation in both Drosophila and human cells. PMID: 27138857
  16. Data show that 5-hydroxytryptamine receptor (5-HT1DR) played an important role in cell invasion via Axin1/beta-catenin/matrix metalloproteinase 7 (MMP-7) pathway. PMID: 26214021
  17. GSK3 acts through APC motifs R2 and B to regulate APC:Axin interactions, promoting high-throughput of betacatenin to destruction. PMID: 26393419
  18. We have offered primary evidence that the T allele and T/T genotype of rs370681 polymorphisms and C/T genotype of rs1805105 polymorphisms in AXIN1 gene are more frequent in patients with cryptorchidism. PMID: 25802106
  19. Higher expression of AXIN1 protein in IUGR placentae indicates a role of Wnt/beta-catenin signaling pathway in pathology of placental development. PMID: 24846767
  20. This study study showed that HMGA2 was able to elicit EMT and regulate several genes which are closely related to the Wnt/beta-catenin pathway by directly binding to their promoter. PMID: 23135750
  21. Significantly increased atrial septal defect risk was observed to be associated with the A allele of rs12921862 PMID: 25355064
  22. suggest a novel mechanism of Wnt signaling through the dissociation of the beta-catenin destruction complex by Axin1 Thr160 modification PMID: 25735981
  23. In adenomatous polyposis coli, beta-catenin phosphorylation involves Axin and the 20 amino acids of APC or APCL. PMID: 24722208
  24. Which destabilize beta-catenin through stabilizing Axin. PMID: 24419084
  25. Gastric neoplasia of chief cell-predominant type (GN-CCP) as a unique variant of nonaggressive tumor are characterized by nuclear beta-catenin accumulation and mutation of CTNNB1 or AXIN gene, suggesting activation of the Wnt/beta-catenin pathway. PMID: 24011952
  26. The expression levels of CTNNB1, AXIN1 and APC did not correlate with the beta-catenin mutation status, which corroborates previous gene expression micro-array analyses PMID: 23525311
  27. methylation status of the Axin gene may be one important factor to predict radiosensitivity of lung cancer. PMID: 23915259
  28. In invasive breast cancer preserved Axin expression is associated with a more aggressive phenotype and reduced survival. PMID: 23278310
  29. Our study revealed that alterations of AXIN1 were involved in hepatitis B virus-related hepatocellular carcinoma PMID: 23879168
  30. X-radiation and siRNA inhibit expression of HDAC1 and HDAC2, weaken the inhibitory effect of HDAC on Axin, upregulate Axin expression and induce apoptosis of lung cancer cells PMID: 23110995
  31. Abnormal hypermethylation of Axin gene is associated with lung cancer. PMID: 23192643
  32. HectD1 promotes the APC-Axin interaction to negatively regulate Wnt signaling. PMID: 23277359
  33. Despite the absence of AXIN1 gene mutations, the low level of Axin-1 protein in the cytoplasm probably also plays a role in tumorigenesis. PMID: 21769465
  34. Phosphorylation of axin-1 by glycogen synthase kinase(GSK)-3beta accelerates the association of axin-1 with beta-catenin. PMID: 22933777
  35. respiratory epithelial polygonal and cuboidal cells have distinct expression of beta-catenin, Axin, and C-myc PMID: 22614067
  36. Low axin1 is associated with hepatocellular carcinoma. PMID: 22524844
  37. Results demonstrate that beta-catenin is not only phosphorylated inside the APC/Axin1 destruction complex, but also ubiquinated and degraded via the proteasome, all within an intact Axin1 complex. PMID: 22682247
  38. 3 synonymous alterations (p.P39P, p.D260D, p.V383V)were found in patients with ALL and one novel synonymous alteration (p.G67G) in the cohort with AML. A new g.G42525A variation was seen in intron 4-5 in 3 patients with acute leukemia. PMID: 21902576
  39. Wnt/beta-catenin signaling and AXIN1 may regulate the efficacy of inhibitors of BRAF(V600E), suggesting that manipulation of the Wnt/beta-catenin pathway could be combined with BRAF inhibitors to treat melanoma PMID: 22234612
  40. These results reveal an important mode of Myc activation in human breast cancer and a mechanism contributing to Myc deregulation involving unique insight into inactivation of the Axin1 tumor suppressor in breast cancer. PMID: 21808024
  41. RNF146 RING-type ubiquitin E3 ligase as a positive regulator of Wnt signaling that operates with tankyrase to maintain low steady-state levels of Axin proteins PMID: 21799911
  42. Axin I expression was investigated in 42 patients with glioblastoma, the most aggressive form of glial tumors. Immunostaining and image analysis revealed the quantity and localization of the protein. PMID: 21648318
  43. methylation of Axin by PRMT1 may serve as a finely tuned regulation mechanism for Wnt/beta-catenin signaling. PMID: 21242974
  44. axin associates with ubiquitin-specific protease 34 (USP34); results indicate USP34 controls the levels of axin and positively modulate Wnt signaling by acting downstream of beta-catenin stabilization through controlling the nuclear accumulation of axin PMID: 21383061
  45. found that dominant-negative mutants of PML blocked AXIN-induced p53 activation, and that AXIN promotes PML sumoylation, a modification necessary for PML functions PMID: 21057547
  46. these results support a model in which the unfolded nature of these critical scaffolding regions in Axin1 facilitates dynamic interactions with a kinase and its substrate, which in turn act upon each other. PMID: 21087614
  47. Study demonstrate that the DIX domains of Dvl and Axin are expressed noticeably in a multi-cistronic system but not in a mono-cistronic system. PMID: 20846493
  48. Down regulation of axin expression and up regulation of beta-catenin were detected in neuroepithelial brain tumors PMID: 19633924
  49. MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway PMID: 20128690
  50. Axin downregulates TCF-4 transcription via beta-catenin and independently of p53. PMID: 20122174

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Involvement in disease Hepatocellular carcinoma (HCC); Caudal duplication anomaly (CADUA)
Subcellular Location Cytoplasm, Nucleus, Membrane, Cell membrane
Tissue Specificity Ubiquitously expressed.
Database Links

HGNC: 903

OMIM: 114550

KEGG: hsa:8312

STRING: 9606.ENSP00000262320

UniGene: Hs.592082

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