BECN1 Antibody, FITC conjugated

Datasheet
Code CSB-PA617917LC01HU
Size US$299
Uniprot No. Q14457
Immunogen Recombinant Human Beclin-1 protein (1-100AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Plays a central role in autophagy (PubMed:23184933). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense.
Form Liquid
Conjugate FITC
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa], BECN1, GT197
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Research Area Epigenetics and Nuclear Signaling
Target Names BECN1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Still Have Questions? Leave a Message or Start an on-line Chat
Function Plays a central role in autophagy
Subcellular Location Cytoplasm, Golgi apparatus, trans-Golgi network membrane, Peripheral membrane protein, Endosome membrane, Peripheral membrane protein, Endoplasmic reticulum membrane, Peripheral membrane protein, Mitochondrion membrane, Peripheral membrane protein, Endosome, Cytoplasmic vesicle, autophagosome
Protein Families Beclin family
Tissue Specificity Ubiquitous.
Database Links

HGNC: 1034

OMIM: 604378

KEGG: hsa:8678

STRING: 9606.ENSP00000355231

UniGene: Hs.716464

Pathway Autophagy
Apelin signaling pathway

Related Products

BECN1 Antibodies

BECN1 Antibodies for Homo sapiens (Human)

BECN1 Antibodies for

BECN1 Antibodies for Human

BECN1 Proteins

BECN1 Proteins for Homo sapiens (Human)

Most popular with customers

Newsletters

Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

Copyright © 2007-2018 www.cusabio.com CUSABIO TECHNOLOGY LLC All Rights Reserved.

Wait!

Join the 25,000 subscribers to get research hotpots, technical tips, latest information on events, sales and offers.

Sign up now!

We don't deal in spam.