BHLHA15 Antibody, HRP conjugated

Datasheet
Code CSB-PA755911LB01HU
Size US$299
Uniprot No. Q7RTS1
Immunogen Recombinant Human Class A basic helix-loop-helix protein 15 protein (2-72AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity).
Form Liquid
Conjugate HRP
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Class A basic helix-loop-helix protein 15 (bHLHa15) (Class B basic helix-loop-helix protein 8) (bHLHb8) (Muscle, intestine and stomach expression 1) (MIST-1), BHLHA15, BHLHB8 MIST1
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Research Area Epigenetics and Nuclear Signaling
Target Names BHLHA15
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity).
Subcellular Location Nucleus
Tissue Specificity Expressed in brain, liver, spleen and skeletal muscle.
Database Links

HGNC: 22265

OMIM: 608606

KEGG: hsa:168620

STRING: 9606.ENSP00000326391

UniGene: Hs.511979

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