BMP4 Antibody, Biotin conjugated

Code CSB-PA05799D0Rb
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) BMP4 Polyclonal antibody
Uniprot No. P12644
Target Names BMP4
Alternative Names zgc:100779 antibody; BMP 2B antibody; BMP 4 antibody; BMP-2B antibody; BMP-4 antibody; BMP2B antibody; BMP2B1 antibody; BMP4 antibody; BMP4_HUMAN antibody; Bone morphogenetic protein 2B antibody; Bone morphogenetic protein 4 antibody; DVR4 antibody; MCOPS6 antibody; MGC100779 antibody; OFC11 antibody; zbmp-4 antibody; ZYME antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Bone morphogenetic protein 4 protein (303-408AA)
Immunogen Species Homo sapiens (Human)
Conjugate Biotin
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).
Gene References into Functions
  1. The expression of BMP4 and FGF8 corelates well with the proliferative component of the pathologies, indicating a possible role in the pathogenesis and progression of Odontogenic Cyst and Tumors. PMID: 30079292
  2. We detected a haplotype-based interaction for BMP4 and IRF6 genes for expression of the orofacial cleft phenotype. Although the MDR methods indicate that the effect of interaction between these genes appears to be mild, the presence of specific haplotype combinations conferring a higher risk for NSCL/P reveals the possible combined role of these genes in the pathogenesis of this prevalent birth defect. PMID: 28133786
  3. Data show that bone morphogenetic protein 4 (BMP4) expression is associated and favored type II macrophage differentiation. PMID: 28928159
  4. MiR-876-5p suppresses epithelial-mesenchymal transition of lung cancer by directly down-regulating BMP-4. PMID: 29229885
  5. endothelial BMP4 controls leukocyte recruitment through a VE-cadherin-dependent mechanism and BMP4-induced inflammation might be involved in the pathogenesis of endothelial cell damage following successful resuscitation after cardiac arrest. PMID: 28755278
  6. Studied serum levels of bone morphogenic protein-4 (BMP-4) and matrix Gla protein (MGP) in patients who were admitted to emergency department with the diagnosis of acute coronary syndrome (ACS) and underwent primary percutaneous coronary intervention. MGP and BMP-4 levels were significantly elevated when compared to subjects with normal coronary arteries. PMID: 28605143
  7. BMP4 inhibits epithelial-mesenchymal transition of the retinal pigment epithelium. PMID: 27586653
  8. Potentially functional and tagging SNPs of BMP2 (rs170986, rs1979855, rs1980499, rs235768, rs3178250) and BMP4 (rs17563, rs4898820, rs762642) were genotyped in NSCLC. PMID: 28574846
  9. BMP4 polymorphic site rs4901474 (T>C) had an effect on hypertension; CC genotype carriers had a 1.48-fold risk for hypertension at the age of 50 years when compared with T-allele carriers PMID: 29390526
  10. High serum BMP4 levels are associated with postmenopausal osteoporosis. PMID: 28238166
  11. results indicate that the BMP4 rs17563 variant is likely to confer a protective effect against the occurrence of Non-Syndromic Cleft Lip with or without Cleft Palate in a sample of the southeast Iranian population. PMID: 29211286
  12. cardiomyocyte (CM) conditioned medium can trigger the recruitment of pro-inflammatory (M1) macrophages, through a mechanism that involves, in part, CM-derived BMP4. PMID: 26103914
  13. BMP4 participates in the regulation of invasion and migration by EC109/Taxol cells PMID: 28315766
  14. Bone morphogenetic protein 4 regulates expression of microRNAs miR-494 and miR-126-5p to control endothelial cell function in angiogenesis. PMID: 28124060
  15. BMP4 expression was significantly increased in HCC tissue, and was correlated with tumor de-differentiation and unfavorable prognosis. BMP4 promoted HCC EMT and was correlated with OXA resistance. PMID: 28987388
  16. Gene expression profiling showed that MuSK was required for the BMP4-induced expression of a subset of genes in myoblasts, including regulator of G protein signaling 4 (Rgs4). PMID: 27601729
  17. BMP4 levels are increased dramatically in individuals with impaired glucose tolerance and type 2 diabetes. PMID: 27524617
  18. The results suggest that selective RNA decay via TGF-beta and BMP4 signaling is critical for specifying the developmental fate of specific human embryonic cell lineages. PMID: 27304915
  19. Expression of bone morphogenetic protein (BMP) 4, an upstream stimulator of SOX9, was upregulated by CG. PMID: 27931264
  20. Study shows that BMP4 is overexpressed in hepatocellular carcinoma (HCC) tissues and BMP4-induced ID2/CDKN1B signaling facilitates the proliferation of HCC. PMID: 28543546
  21. we demonstrate that expression of bone morphogenetic protein 4 (BMP-4) is universally upregulated in human colorectal cancer cells and tissues, resulting in activated BMP signaling PMID: 28611046
  22. RUNX1T1 serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells PMID: 28640846
  23. Phosphorylated Smad1/5/8/9 specifically bound to the BREs of Smad8/9 gene. The present study reveals that Smad8/9 is a unique R-Smad regulated through the BMP pathway at the mRNA level. PMID: 26748560
  24. Meta-analysis to assess the effect of BMP4 rs17563 polymorphism on nonsyndromic cleft lip with or without cleft palate (NSCL/P) suggests that the C allele of BMP4 rs17563 may be a risk factor for NSCL/P among Asians and Caucasians, and may be a protective factor for NSCL/P in Brazilian population. PMID: 28767592
  25. this study identified BMP-4 as a potential molecular marker for predicting the invasion and progression of papillary thyroid carcinoma PMID: 28214211
  26. Bmp4 drives terminal differentiation into mature white rather than brown fat cells. Bmp4 seems to have a dual role in metabolism either promoting or repressing oxidative metabolism in a cell context dependent manner. PMID: 28425843
  27. Data suggest that serum BMP4 levels are associated with visceral adiposity and may play role in fat distribution; role of BMP4 in males and females may be different; visceral adiposity may predict serum BMP4 levels in females with obesity; serum BMP4 levels are decreased after GLP-1 receptor agonist (exenatide) treatment in obesity. This study was conducted in China. PMID: 28376799
  28. BMP4 is a potential cause of digital and eye abnormalities in familial dopa-responsive dystonia. PMID: 28558098
  29. BMP4 expression was significantly upregulated in esophageal adenocarcinoma and Barrett's esophagus. BMP4 incubation inhibited cell viability,induced cell migration adnd upregulated SNAIL2 expression. PMID: 27191723
  30. the data identify MxA as a novel stimulator of BMP4 and BMP9 transcriptional signaling, and suggest it to be a candidate IFN-alpha-inducible mechanism that might have a protective role against development of pulmonary arterial hypertension and other vascular diseases. PMID: 27875556
  31. The 6007C>T polymorphism of BMP-4, -66T>G polymorphism of OPN, and VDR-FokI polymorphism are the susceptible factors of spinal TB and indicators of the clinical severity. These three genes may collaborate in the development of spinal TB. PMID: 28376475
  32. The results suggest that Osterix plays an important role in increasing BMP- 4-induced Cx43 activity. PMID: 27498006
  33. inhibitory role on glucagon secretion, pancreatic alpha-cell growth, and expression of genes maintaining alpha-cell identity PMID: 27479530
  34. BMP4 promotes a phenotype change of an esophageal squamous epithelium via up-regulation of KLF4. PMID: 27693253
  35. Study demonstrated that Chrdl1 acts as an inhibitor of BMP4-induced migration and invasion which stimulated breast cancer cell invasion and matrix degradation, in part, through MMP2 and MMP9 activity that is antagonized by Chrdl1. PMID: 26976638
  36. BMP4 GAAA (p=0.05) and GGGA (p=0.02) haplotypes were associated with peri-implantitis (p=0.03). Therefore, it may be concluded that BMP4 and FGF10 haplotypes are associated with peri-implantitis PMID: 27652695
  37. BMP4 inhibited ERalpha signaling by increasing the degradation of ERalpha, and that the expression of BMP4 itself was suppressed by estrogens. PMID: 27522322
  38. study shows that patients with CRA had high expression of BMP6 and hepcidin and low expression of s-HJV. BMP6 was found to be negatively correlated with s-HJV; both regulate hepcidin expression and play important roles in the development of anemia. PMID: 27051019
  39. we have for the first time characterized the BMP4-induced miRNA expression profiles in breast cancer cell lines, showing that induced miRNAs contribute to the fine-tuning of proliferation and migration phenotypes. PMID: 26684238
  40. BMP4 caused a trend towards accelerated metastasis formation, especially in bone. More work is needed to uncover the long-term effects of BMP4 and the clinical relevance of these findings. PMID: 26970275
  41. BMP4 is a direct thyroid hormone target and is involved in a positive autoregulatory feedback loop that modulates thyroid hormone signaling PMID: 26676745
  42. An up-regulated expression of BMP-4 and BMPR-II was observed in the peripheral blood of breast cancer patients especially in the advanced-stage of the disease. Moreover, BMP-4 and BMPR-II expressions were found to be correlated PMID: 26406943
  43. PDGF-AA impairs endothelium-dependent vasodilation and PDGF-AA mediates BMP4-induced adverse effect on endothelial cell function through SMAD1/5- and SMAD4-dependent mechanisms. PMID: 26769046
  44. BMP4 gene is involved in the ATO regulation of adipogenic and osteogenic differentiation balance, which provides a new target for the treatment of AA PMID: 26215597
  45. Overexpression of the BMP4/SMAD4/SMAD5 signaling pathway could predict poor clinical outcome in skull base chordomas, suggesting activation of this pathway is involved in chordoma pathogenesis. PMID: 26339396
  46. HIF-1alpha knockdown attenuated hypoxia-induced BMP4 expression and knockdown of either HIF-1alpha or BMP4 abolished hypoxia-induced TRPC expression and basal [Ca(2+)]i. PMID: 25824146
  47. The effect of TGF-beta1 and BMP-4 on bone marrow-derived stem cell morphology on a novel bioabsorbable nanocomposite material. PMID: 24245787
  48. Suggest that hypermethylation of ACP1, BMP4, and TSPYL5 are common events in HCC and could be used as potentially detectable biomarkers in HCC tissues. PMID: 26386860
  49. Additive Effects of Retinoic Acid (RA) and Bone Morphogenetic Protein 4 (BMP-4) Apoptosis Signaling in Retinoblastoma Cell Lines PMID: 26173116
  50. findings support a role of the BMP4 gene in the aetiology of non-syndromic CL/CLP and CP in the Latvian and Lithuanian populations. PMID: 25471993

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Involvement in disease Microphthalmia, syndromic, 6 (MCOPS6); Non-syndromic orofacial cleft 11 (OFC11)
Subcellular Location Secreted, extracellular space, extracellular matrix
Protein Families TGF-beta family
Tissue Specificity Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines.
Database Links

HGNC: 1071

OMIM: 112262

KEGG: hsa:652

STRING: 9606.ENSP00000245451

UniGene: Hs.68879

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