CABIN1 Antibody, Biotin conjugated

Datasheet
Code CSB-PA23399D0Rb
Size US$299
Uniprot No. Q9Y6J0
Protocols ELISA Protocol
Immunogen Recombinant Human Calcineurin-binding protein cabin-1 protein (1978-2123AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes.
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN), CABIN1, KIAA0330
Immunogen Species Homo sapiens (Human)
Research Area Signal Transduction
Target Names CABIN1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes.
Subcellular Location Nucleus
Tissue Specificity Widely expressed in different tissues.
Database Links

HGNC: 24187

OMIM: 604251

KEGG: hsa:23523

STRING: 9606.ENSP00000263119

UniGene: Hs.517478

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