CAND1 Antibody, Biotin conjugated

Datasheet
Code CSB-PA774815LD01HU
Size US$299
Uniprot No. Q86VP6
Protocols ELISA Protocol
Immunogen Recombinant Human Cullin-associated NEDD8-dissociated protein 1 protein (1150-1230AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes.
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1), CAND1, KIAA0829 TIP120 TIP120A
Immunogen Species Homo sapiens (Human)
Research Area Epigenetics and Nuclear Signaling
Target Names CAND1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation
Subcellular Location Cytoplasm, Nucleus
Protein Families CAND family
Database Links

HGNC: 30688

OMIM: 607727

KEGG: hsa:55832

STRING: 9606.ENSP00000299218

UniGene: Hs.546407

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