CARMIL1 Antibody, Biotin conjugated

Datasheet
Code CSB-PA713356LD01HU
Size US$299
Uniprot No. Q5VZK9
Immunogen Recombinant Human F-actin-uncapping protein LRRC16A protein (1184-1295AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667).
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A), CARMIL1, CARMIL LRRC16 LRRC16A
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Research Area Signal Transduction
Target Names CARMIL1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments
Subcellular Location Cytoplasm, Cytoplasm, cytoskeleton, Cell membrane, Cell projection, lamellipodium
Protein Families CARMIL family
Tissue Specificity Expressed in lung, placenta, small intestine, liver, thymus, colon, skeletal muscle, heart and brain. Higher expression in kidney.
Database Links

HGNC: 21581

OMIM: 609593

KEGG: hsa:55604

STRING: 9606.ENSP00000331983

UniGene: Hs.649550

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