CASP5 Antibody, FITC conjugated

Code CSB-PA004550LC01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) CASP5 Polyclonal antibody
Uniprot No. P51878
Target Names CASP5
Alternative Names Apoptosis related cysteine protease antibody; CASP-5 antibody; CASP5 antibody; CASP5_HUMAN antibody; Caspase-5 subunit p10 antibody; ICE(rel)-III antibody; ICERELIII antibody; ICH 3 antibody; ICH 3 protease antibody; Protease ICH-3 antibody; Protease TY antibody; TY antibody; TY protease antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Caspase-5 protein (137-327AA)
Immunogen Species Homo sapiens (Human)
Conjugate FITC
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Thiol protease that acts as a mediator of programmed cell death. Initiates pyroptosis, a programmed lytic cell death pathway through cleavage of Gasdermin-D (GSDMD): cleavage releases the N-terminal gasdermin moiety (Gasdermin-D, N-terminal) that binds to membranes and forms pores, triggering pyroptosis. During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation.
Gene References into Functions
  1. Long non-coding RNA CASP5 promotes the malignant phenotypes of human glioblastoma multiforme. PMID: 29715460
  2. Study shows that CASP5 was positively correlated with inflammation in rheumatoid arthritis (RA), and provides evidence that certain CASP5 SNPs were associated with an increased risk of RA. PMID: 29158166
  3. Th17 micro-milieu via IL-17A regulates NLRP1-dependent CASP5 activity in psoriatic skin autoinflammation. PMID: 28422993
  4. CASP5 gene overexpression significantly promoted angiogenesis ability of HMEC-1 cells, which was probably achieved by inhibiting angpt-1/Tie2 and promoting VEGF-1 signal pathway. PMID: 26884849
  5. The distribution of the other genotypes; rs507879, rs518604 and rs523104 of caspase-5) was not significantly different between patients with psoriasis vulgaris and the healthy controls. PMID: 25753570
  6. Data show that exposure of hepatocytes to direct hypoxia resulted in acid sphingomyelinase activation and ceramide elevation associated with activation of caspase 5 and the subsequent cleavage of HuR and apoptotic cell death. PMID: 22906436
  7. Mutual activation between caspase-5 and -1 suggests caspase-5 may work predominantly in concert with caspase-1 in modulating retinal pigment epithelium inflammatory responses. PMID: 21969293
  8. analysis of concerted antigen processing of a short viral antigen by human caspase-5 and -10 PMID: 21454616
  9. Caspase-5 and the inflammasome may have an important role in the inflammatory response in psoriasis. PMID: 21191419
  10. Unfavorable significance of CASP5 heterozygous genotype explained by its role in inflammation-related processes. PMID: 20434535
  11. Identification of caspase-5 coding region microsatellite mutations in vivo implicates this gene in the pathogenesis of human T-LBL/ALL PMID: 12479849
  12. Caspase-5 might be a suppressor gene of highly metastatic potential in lung cancer PMID: 12964016
  13. CASPASE-5, an acknowledged frameshift target in MSI+ gastrointestinal tract tumors, was frequently mutated in Microsatellite instability+ cell lines PMID: 15886296
  14. novel exon was present in six alternatively spliced caspase-5 mRNA variants expressed in human peripheral blood mononuclear cells (PBMC) and encoded the previously unknown amino-terminus of caspase-5. PMID: 16893518
  15. Caspase-5 gene is commonly mutated in the cancers with microsatellite instability suggesting that inactivation of caspase-5 may play a role in their tumorigenesis. PMID: 18430458
  16. Coding polymorphisms in Casp5, Casp8 and DR4 genes may play a role in predisposition to lung cancer. PMID: 19203830
  17. Single nucleotide polymorphisms in CASP5 and RBBP8 gene are associated with survival in ovarian cancer patients. PMID: 19270026

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Protein Families Peptidase C14A family
Tissue Specificity Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle.
Database Links

HGNC: 1506

OMIM: 602665

KEGG: hsa:838

STRING: 9606.ENSP00000376849

UniGene: Hs.213327

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