CD86 Antibody, HRP conjugated

Datasheet
Code CSB-PA004965EB01HU
Size US$299
Uniprot No. P42081
Protocols ELISA Protocol
Immunogen Recombinant Human T-lymphocyte activation antigen CD86 protein (24-247AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. (Microbial infection) Acts as a receptor for adenovirus subgroup B.
Form Liquid
Conjugate HRP
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias T-lymphocyte activation antigen CD86 (Activation B7-2 antigen) (B70) (BU63) (CTLA-4 counter-receptor B7.2) (FUN-1) (CD antigen CD86), CD86, CD28LG2
Immunogen Species Homo sapiens (Human)
Research Area Immunology
Target Names CD86
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.; FUNCTION
Subcellular Location Cell membrane, Single-pass type I membrane protein
Tissue Specificity Expressed by activated B-lymphocytes and monocytes.
Database Links

HGNC: 1705

OMIM: 601020

KEGG: hsa:942

STRING: 9606.ENSP00000332049

UniGene: Hs.171182

Pathway Toll-like receptor signaling pathway

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