CDC42 Antibody, FITC conjugated

Datasheet

Code CSB-PA005008DC01HU
Size US$299
Uniprot No. P60953
Immunogen Recombinant human Cell division control protein 42 homolog protein (2-188AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.
Form Liquid
Conjugate FITC
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Cell division control protein 42 homolog (G25K GTP-binding protein), CDC42
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Research Area Cell Biology
Target Names CDC42
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups.
Involvement in disease Takenouchi-Kosaki syndrome (TKS)
Subcellular Location Cell membrane, Lipid-anchor, Cytoplasmic side, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cytoplasm, cytoskeleton, spindle, Midbody
Protein Families Small GTPase superfamily, Rho family, CDC42 subfamily
Database Links

HGNC: 1736

OMIM: 116952

KEGG: hsa:998

STRING: 9606.ENSP00000314458

UniGene: Hs.467637

Pathway Chemokine signaling pathway
MAPK signaling pathway
VEGF signaling pathway
Focal adhesion
Regulation of actin cytoskeleton
Adherens junction
Ras signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
T cell receptor signaling pathway
AGE-RAGE signaling pathway in diabetic complications
Rap1 signaling pathway
Endocytosis
Neurotrophin signaling pathway

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