CELF6 Antibody, FITC conjugated

Datasheet
Code CSB-PA822233LC01HU
Size US$299
Uniprot No. Q96J87
Immunogen Recombinant Human CUGBP Elav-like family member 6 protein (292-395AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in a muscle-specific splicing enhancer (MSE)-dependent manner. Promotes also exon exclusion of INSR pre-mRNA.
Form Liquid
Conjugate FITC
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias CUGBP Elav-like family member 6 (CELF-6) (Bruno-like protein 6) (CUG-BP- and ETR-3-like factor 6) (RNA-binding protein BRUNOL-6), CELF6, BRUNOL6
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Research Area Epigenetics and Nuclear Signaling
Target Names CELF6
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in a muscle-specific splicing enhancer (MSE)-dependent manner. Promotes also exon exclusion of INSR pre-mRNA.
Subcellular Location Nucleus, Cytoplasm
Protein Families CELF/BRUNOL family
Tissue Specificity Expressed mainly in kidney, brain and testis and present in other tissues albeit at lower levels. Also expressed in fetal kidney.
Database Links

HGNC: 14059

OMIM: 612681

KEGG: hsa:60677

STRING: 9606.ENSP00000287202

UniGene: Hs.348342

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