CENPA Antibody, Biotin conjugated

Code CSB-PA005205LD01HU
Size US$299
Uniprot No. P49450
Protocols ELISA Protocol
Immunogen Recombinant Human Histone H3-like centromeric protein A protein (1-50AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A), CENPA
Immunogen Species Human
Research Area Epigenetics and Nuclear Signaling
Target Names CENPA
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes
Subcellular Location Nucleus, Chromosome, centromere, kinetochore, Chromosome, centromere
Protein Families Histone H3 family
Database Links

HGNC: 1851

OMIM: 117139

KEGG: hsa:1058

STRING: 9606.ENSP00000336868

UniGene: Hs.1594

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