CHAF1A Antibody, Biotin conjugated

Datasheet
Code CSB-PA618758LD01HU
Size US$299
Uniprot No. Q13111
Protocols ELISA Protocol
Immunogen Recombinant Human Chromatin assembly factor 1 subunit A protein (840-904AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci (By similarity).
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-I p150) (hp150), CHAF1A, CAF CAF1P150
Immunogen Species Homo sapiens (Human)
Research Area Epigenetics and Nuclear Signaling
Target Names CHAF1A
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci (By similarity).
Subcellular Location Nucleus
Protein Families CHAF1A family
Database Links

HGNC: 1910

OMIM: 601246

KEGG: hsa:10036

STRING: 9606.ENSP00000301280

UniGene: Hs.79018

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