CNNM2 Antibody

Code CSB-PA001905
Size US$100
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  • Western Blot analysis of A549 cells using Cyclin M2 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
CNNM2
Alternative Names
ACDP2 antibody; Ancient conserved domain containing protein 2 antibody; Ancient conserved domain protein 2 antibody; Ancient conserved domain-containing protein 2 antibody; CNNM 2 antibody; CNNM2 antibody; CNNM2_HUMAN antibody; Cyclin M2 antibody; Cyclin-M2 antibody; Metal transporter CNNM2 antibody; OTTHUMP00000020387 antibody; OTTHUMP00000020388 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the Internal region of Human Cyclin M2.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:10000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+).
Gene References into Functions
  1. CNNM2 single nucleotide polymorphisms association with the risk of hypertension in Chinese Han population. PMID: 30180964
  2. In this large-scale, Han Chinese population-based genetic association study for genetic susceptibility to schizophrenia of a three-gene cluster region, AS3MT-CNNM2-NT5C2, two SNPs with independent effects, rs11191419 and rs11191514, were identified. Rs11191419 is located on the 5' (potential promoter) region of AS3MT, while rs11191514 is located in one of the introns of CNNM2. PMID: 27401531
  3. this study implicates altered neural expression of BORCS7, AS3MT, and NT5C2 in susceptibility to schizophrenia arising from genetic variation at the chromosome 10q24 locus PMID: 27004590
  4. Sensitivity of CNNM2 expression to extracellular Mg(2+) depletion depends on cell type. PMID: 27068403
  5. meta-analysis of two Caucasian cohorts did not show an association between five aneurysm associated loci and sporadic brain Arteriovenous malformations. PMID: 25053769
  6. The T568I mutation causes the magnesium transporter, CNNM2, to become 'locked' in its flat form. PMID: 25184538
  7. Cells expressing mutated CNNM2 proteins did not show increased Mg(2+) uptake. PMID: 24699222
  8. This CNNM2 risk variant rs7914558 may have an impact on neural systems relevant to social cognition. PMID: 24311551
  9. Our findings suggest that the genetic variant in the CNNM2 gene could be implicated in the pathogenesis of schizophrenia through the gray matter volumetric vulnerability of the orbital regions in the inferior frontal gyri. PMID: 24160291
  10. crystals of CNNM2 belonged to space groups P2(1)2(1)2 and I222 (or I2(1)2(1)2(1)) and diffracted X-rays to 2.0 and 3.6 A resolution, respectively, using synchrotron radiation PMID: 23027747
  11. analysis of structure of CNNM2 and its post-translational modifications PMID: 22399287
  12. ACDP2 splice-variant 1 is a functional Mg2+-transporting entity per se. PMID: 20519162
  13. The CNNM2 locus is associated with serum Mg(2+) concentrations. PMID: 21397062

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Involvement in disease
Hypomagnesemia 6 (HOMG6); Hypomagnesemia, seizures, and mental retardation (HOMGSMR)
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
ACDP family
Tissue Specificity
Widely expressed. Expressed at higher level in brain, kidney and placenta, while it is weakly expressed in skeletal muscle. In the kidney, it is expressed in the distal convoluted tubule and the thick ascending limb of Henle loop.
Database Links

HGNC: 103

OMIM: 607803

KEGG: hsa:54805

STRING: 9606.ENSP00000358894

UniGene: Hs.643509

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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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