CYFIP1 Antibody, Biotin conjugated

Datasheet
Code CSB-PA748722LD01HU
Size US$299
Uniprot No. Q7L576
Protocols ELISA Protocol
Immunogen Recombinant Human Cytoplasmic FMR1-interacting protein 1 protein (320-449AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). May act as an invasion suppressor in cancers.
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1) (p140sra-1), CYFIP1, KIAA0068
Immunogen Species Homo sapiens (Human)
Research Area Others
Target Names CYFIP1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). May act as an invasion suppressor in cancers.
Subcellular Location Cytoplasm, Cytoplasm, perinuclear region, Cell projection, lamellipodium, Cell projection, ruffle, Cell junction, synapse, synaptosome
Protein Families CYFIP family
Database Links

HGNC: 13759

OMIM: 606322

KEGG: hsa:23191

STRING: 9606.ENSP00000324549

UniGene: Hs.26704

Pathway Regulation of actin cytoskeleton

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