Ccl12 Antibody, Biotin conjugated

Code CSB-PA09139D0Rb
Size US$299
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Product Details

Full Product Name Rabbit anti-Mus musculus (Mouse) Ccl12 Polyclonal antibody
Uniprot No. Q62401
Target Names Ccl12
Alternative Names C-C motif chemokine 12 antibody; Ccl12 antibody; CCL12_MOUSE antibody; Macrophage/monocyte Chemotactic Protein antibody; MCP-1-related chemokine antibody; MCP-5 antibody; Monocyte chemoattractant protein 5 antibody; Monocyte chemotactic protein 5 antibody; OTTMUSP00000000792 antibody; Scya12 antibody; Small inducible cytokine A12 antibody; Small-inducible cytokine A12 antibody
Raised in Rabbit
Species Reactivity Mouse
Immunogen Recombinant Mouse C-C motif chemokine 12 ptotein (23-104AA)
Immunogen Species Mus musculus (Mouse)
Conjugate Biotin
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Chemotactic factor that attracts eosinophils, monocytes, and lymphocytes but not neutrophils. Potent monocyte active chemokine that signals through CCR2. Involved in allergic inflammation and the host response to pathogens and may play a pivotal role during early stages of allergic lung inflammation.
Gene References into Functions
  1. After 100% O2 treatment, genes involved in inflammation (Ccl12), angiogenesis (Igfr1, Stat3), and metabolism (Hk2) were upregulated. PMID: 24458145
  2. Data indicate mRNA upregulation of CCR2 and CCR2 ligands CCL2, CCL7, CCL8, and CCL12 in aortas from DOCA/salt-treated hypertension. PMID: 23033370
  3. The transforming growth factor (TGF)beta type II receptor/MCP-5 axis is an essential crossroad for joint development and endochondral growth. PMID: 22814601
  4. CCL12 proteins were present in the vast majority of tissues investigated. mRNA for these proteins was also expressed in most of these tissues suggesting local production and the ability to respond in situ to inflammatory stimuli. PMID: 20931267
Subcellular Location Secreted.
Protein Families Intercrine beta (chemokine CC) family
Tissue Specificity Predominantly expressed in the lymph nodes and thymus. Also found in the salivary glands containing lymph nodes, breast, heart, lung, brain, small intestine, kidney and colon.
Database Links

KEGG: mmu:20293

STRING: 10090.ENSMUSP00000000194

UniGene: Mm.867

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