Cd74 Antibody, HRP conjugated

Code CSB-PA004956LB01MO
Size US$299
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Product Details

Full Product Name Rabbit anti-Mus musculus (Mouse) Cd74 Polyclonal antibody
Uniprot No. P04441
Target Names Cd74
Alternative Names Cd74 antibody; Ii antibody; H-2 class II histocompatibility antigen gamma chain antibody; Ia antigen-associated invariant chain antibody; Ii antibody; MHC class II-associated invariant chain antibody; CD antigen CD74) [Cleaved into: Class-II-associated invariant chain peptide antibody; CLIP)] antibody
Raised in Rabbit
Species Reactivity Mouse
Immunogen Recombinant Mouse H-2 class II histocompatibility antigen gamma chain protein (56-279AA)
Immunogen Species Mus musculus (Mouse)
Conjugate HRP
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44.; Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs).; Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome.
Gene References into Functions
  1. House dust mites sensitization lowered humoral immune responses to intact pneumococcus and this effect was significantly modified by the HLA-DR polymorphism. PMID: 27506953
  2. Data highlight the complexity of the MIF/CD74 signaling pathway in the development of mesothelioma. PMID: 26883190
  3. We demonstrate that MHCII is dispensable for the B cell phenotype of (signal peptide peptidase-like 2a) SPPL2a(-/-) mice, further supporting a CD74-intrinsic effect. PMID: 28550201
  4. CLIP expression and activated gamma-delta T cells are responsible for the development of preeclampsia. PMID: 28642294
  5. MIF-CD74 signaling inhibits interferon (IFN)-gamma secretion in microglia through phosphorylation of microglial ERK1/2 (extracellular signal-regulated protein kinases 1 and 2). The inhibition of MIF signaling or its receptor CD74 promotes IFN-gamma release and amplifies tumor death either through pharmacological inhibition or through siRNA-mediated knockdown. PMID: 27157615
  6. Ii mediated pathways play a vital role in the initiation and propagation of liver inflammation. PMID: 27371158
  7. CD74-knockout mice showed disturbed placental morphology, reduced junctional zone, smaller placentas, and impaired spiral artery remodeling with fetal growth restriction. PMID: 27199465
  8. explored CD74 expression, which can form a complex with CD44, in glomerular parietal epithelial cells during the progression of a model of focal segmental glomerulosclerosis PMID: 27463800
  9. might play roles in both the middle ear and inner ear in lipopolysaccharide-induced otitis media PMID: 27181906
  10. Data show that cathepsins S (CatS) regulates CCL2 chemokine expression by modulation of CD74 antigen processing. PMID: 26358505
  11. Suggest that the DQA1*0103/CD74 dimer may result in presentation of unique antigens and susceptibility to develop arthritis. PMID: 26524976
  12. CD74 plays a critical role in the MIF inhibition of osteoclastogenesis. PMID: 23044992
  13. Genetic deletion of CD74 restored the ability of infected dendritic cells to present a parasite antigen in the context of MHC-II. PMID: 26195549
  14. SPPL2a-mediated processing of CD74 NTF is indispensable to maintain appropriate levels of tonic BCR signaling to promote B cell maturation. PMID: 26157172
  15. Results support the hypothesis that neurodegeneration following traumatic brain injury is dependent upon antigen processing and presentation that requires CD74 PMID: 25329434
  16. Methylglyoxal induced gene expression of CD74 in the in the diabetic retina. PMID: 24974304
  17. In TPA-induced skin inflammation, MIF is released from damaged keratinocytes and then triggers the chemotaxis of CD74(+)CXCR2(+) NKT cells for IFN-gamma production. PMID: 25172501
  18. MIF promotes the migration of B cells through a ZAP-70-dependent pathway mediated by cooperative engagement of CXCR4 and CD74. PMID: 24760155
  19. These results demonstrate natural antagonist activity of DRalpha1 for macrophage migration inhibitory factor PMID: 24683185
  20. Recombinant vaccinia virus vaccines encoding CD74 may be useful tools to improve CD4 T-cell responses to viral and tumour antigens. PMID: 24205828
  21. Macrophage migration inhibitory factor receptor CD74 mediates alphavirus-induced arthritis and myositis in murine models of alphavirus infection. PMID: 23896945
  22. These findings implicate binding of recombinant T-cell receptor ligand constructs to CD74 as a key step in both antigen-driven and bystander T-cell tolerance important in treatment of inflammatory diseases. PMID: 23026773
  23. Data show that human Iip35 isoform (CD74 antigen) is expressed in mouse antigen presenting cells. PMID: 22689013
  24. regulation of CD74 levels by SPPL2a is indispensable for B cell development PMID: 23267015
  25. ). Proteolytic processing of CD74 requires SPPL2A. PMID: 23267016
  26. These results emphasize the importance of Ii in B cell homeostasis and suggest that Iip35 could have regulatory functions. PMID: 22966065
  27. demonstrate here a CD74-dependent MHC class I cross-presentation pathway in dendritic cells that had a major role in the generation of MHC class I-restricted, cytolytic T lymphocyte responses to viral protein- and cell-associated antigens PMID: 22306692
  28. The cytokine midkine and its receptor RPTPzeta regulate B cell survival in a pathway induced by CD74. PMID: 22140262
  29. MIF promoted the phosphorylation of AMP-activated protein kinase (AMPK) in a CD74-dependent manner and, in turn, inhibition of AMPK reversed the inhibition of PDGF-induced hepatic stellate cell activation by MIF. PMID: 21969590
  30. iNKT developed in Ii(-/-) but not catS(-/-) mice have defective effector function. PMID: 21565221
  31. Data demonstrate that MIF and CD74 play previously unappreciated roles in CCL2-induced macrophage adhesion and migration. PMID: 21411731
  32. this study emphasizes the role of microvesicles and Ii in the communication between DC and microglia. PMID: 20816669
  33. although other regions of Ii interact with class II, CLIP binding to the groove is likely to be a dominant event in assembly of nascent class II molecules with Ii in the ER PMID: 20547545
  34. expression and function of CD74 in normal colon epithelial cells and colon carcinoma cells PMID: 20614481
  35. Data show that D74-HGF/c-Met axis defines a novel physiologic survival pathway in mature B cells, resulting in the control of the humoral immune response. PMID: 20639480
  36. We here identify Cd74 as a common insertion site in murine B-lymphomas PMID: 20416035
  37. Preferential Th1 immune response in invariant chain knockout mice PMID: 11823488
  38. structure for the trimeric MHC class II-associated invariant chain transmembrane domain PMID: 12126629
  39. Expression and function of transgenic HLA-DQ molecules and lymphocyte development in mice lacking invariant chain. PMID: 12165499
  40. major histocompatibility complex class II-associated invariant chain controls the activity of extracellular cathepsin L PMID: 12417635
  41. Ii and its isoforms are essential to mediate ovalbumin-induced pulmonary inflammation, IgE generation, and airway hyperresponsiveness in a Th2-dependent immune response. PMID: 12538710
  42. Expression of Ii blocks constitutive major histocompatibility (MHC) class II localization to plasma membrane lipid rafts and may reduce vaccine efficiency of M12.C3 B cell lymphoma and SaI-Ak sarcoma tumor vaccine cells. PMID: 14707062
  43. Ii deficiency induces cell autonomous defects of two distinct B cell lineages: the life span of mature follicular B cells is reduced, accounting for their markedly decreased frequency, whereas, in contrast, marginal zone B cells accumulate. PMID: 14764672
  44. In p41 CD74 isoform-transgenic mice on an I-A(d) background (p41-I-A(d) mice), the recovery from CNS injuries was worse than that of controls. PMID: 17182551
  45. Ii siRNA-transfected H-2(K) DCs enhanced Th1 responses. PMID: 17296316
  46. These results suggest that invariant chain-chondroitin sulfate may play an important role in the generation of cell-surface pools of invariant chain that can serve as receptors for CD44 and macrophage migration inhibitory factor. PMID: 17492940
  47. Ii-Key modified HER-2/neu776-790 hybrid peptides are sufficiently potent to provide antigen-specific CD4+ TH cells with therapeutic antitumor activity PMID: 17634957
  48. the CD74/NF-kappaB/TAp63 axis defines a novel antiapoptotic pathway in mature B cells, resulting in the shaping of both the B-cell repertoire and the immune response PMID: 17846227
  49. impact of allelic variation in CLIP affinity on immune responses will be highest in cells with limited DM activity PMID: 17947664
  50. NOS2 interacts with CD74 (the MHC II-associated invariant chain), and the degradation of CD74 by caspases in immature dendritic cells was inhibited upon treatment with nitric oxide donor. PMID: 18003616

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Subcellular Location [Isoform Long]: Late endosome. Lysosome.; Cell membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome.
Tissue Specificity [Isoform Long]: Expressed in thymus and lymph noodes. Expressed by antigen-presenting cells (APCs).; [Isoform Short]: Expressed in thymus and lymph noodes.
Database Links

KEGG: mmu:16149

STRING: 10090.ENSMUSP00000095171

UniGene: Mm.439737

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