Ctsg Antibody, Biotin conjugated

1. these findings present evidence of an arterial-specific recruitment pattern centered on CatG-instructed adhesion strengthening. The inhibition of this process could provide a novel strategy for treatment of arterial inflammation with limited side effects. PMID: 27660294
2. Cathepsin G activity may impair efferocytosis, which could lead to an accumulation of lesion-associated apoptotic cells and the accelerated progression of early atherosclerotic lesions to more complex lesions in Apoe(-/-) mice. PMID: 23934850
3. SerpinB1 is critical for maintaining polymorphonuclear neutrophils survival by antagonizing intracellular cathepsin G activity. PMID: 23532733
4. Cathepsin G-regulated release of formyl peptide receptor agonists modulate neutrophil effector functions. PMID: 22879591
5. Cathepsin G and neutrophil elastase contribute to lung-protective immunity against mycobacterial infections in mice. PMID: 22461690
6. This is the first study showing a contribution of neutrophil-derived neutral serine proteases CG and NE to lung-protective immunity against focal pneumonia-inducing serotype 19 S. pneumoniae in mice. PMID: 21911460
7. In the absence of a pathogen challenge, neutrophil-derived proteases and nucleosomes contribute to large vessels thrombosis, the main trigger of myocardial infarction and stroke. PMID: 20676107
8. Inhibition of TGF-beta significantly reduces microvessel density in mammary tumor-induced bone lesions, mediated by decreased expression of both vascular endothelial growth factor (VEGF) and monocyte chemotactic protein (MCP)-1. PMID: 19646811
9. neutrophil elastase and cathepsin G are inhibited by PAI-1 mutants PMID: 15131125
10. cathepsin G activity at the tumor-bone interface plays an important role in mammary tumor-induced osteolysis through RANKL PMID: 18632634
11. both Cat-G and PAR(4) play key roles in generating and/or amplifying relapses in ulcerative colitis PMID: 19528350
12. Cathepsin G and MMP9 were identified as proteases involved in enhanced TGF-beta signaling at the tumor-bone interface of mammary tumor-induced osteolytic lesions. PMID: 19671689
13. Serine protease required for resistance to microbial infection; contributes to pathogenessis in endotoxic shock PMID: 10714686

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KEGG: mmu:13035

STRING: 10090.ENSMUSP00000015583

UniGene: Mm.4858