Cxcl14 Antibody, HRP conjugated

Code CSB-PA09319B0Rb
Size US$299
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Product Details

Full Product Name Rabbit anti-Mus musculus (Mouse) Cxcl14 Polyclonal antibody
Uniprot No. Q9WUQ5
Target Names Cxcl14
Alternative Names Cxcl14 antibody; Bmac antibody; Kec antibody; Ks1 antibody; Mip2g antibody; Scyb14C-X-C motif chemokine 14 antibody; B-cell and monocyte-activating chemokine antibody; Chemokine BRAK antibody; Kidney-expressed chemokine CXC antibody; MIP-2G antibody; Small-inducible cytokine B14 antibody
Raised in Rabbit
Species Reactivity Mouse
Immunogen Recombinant Mouse C-X-C motif chemokine 14 protein (23-99AA)
Immunogen Species Mus musculus (Mouse)
Conjugate HRP
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Chemotactic for CESS B-cells and THP-1 monocytes, but not T-cells.
Gene References into Functions
  1. Platelets are a relevant source of CXCL14. Platelet-derived CXCL14 at the site of vascular lesions might play an important role in vascular repair/regeneration. PMID: 28359053
  2. CXCL14 Tg mice showed a suppressed rate of carcinogenesis, decreased tumour volume, and reduced pulmonary metastasis, as well as an increased survival rate of mice following tumour cell injection. PMID: 25765541
  3. CXCL14 does not seem to play a pivotal role during influenza and Escherichia coli infections of the lung. PMID: 25313607
  4. CXCL14 was able to promote bone metastasis through enhancement of cancer cell tropism to the bone and/or recruitment of bone marrow cells around metastatic cancer cells. PMID: 24534874
  5. In conclusion, our results suggested the important function of Cxcl14 in uNK cells and the proper level of Cxcl14 protein were required to recruit NK cells to pregnant uterus. PMID: 23688424
  6. the transient expression of CXCL14 by Purkinje cells in the developing cerebellum, suggesting that it must be involved in the postnatal maturation of the cerebellum PMID: 22843118
  7. CXCL14 may play an important role in central nervous system regulation of feeding behavior PMID: 20428232
  8. Study identifies CXCL14 as a novel marker of tendon connective tissue. PMID: 21038449
  9. Murine CXCL14 is dispensable for the homeostatic recruitment of antigen-presenting cells toward the periphery and for LC functionality. PMID: 17130243
  10. CXCL14 is a critical chemoattractant of white adipose tissue macrophages and a novel regulator of glucose metabolism that functions mainly in skeletal muscle. PMID: 17724031
  11. These results suggest that CXCL14 plays a causal role in high-fat diet-induced obesity. PMID: 17971304
  12. Data suggest that despite the structural homology and similarity in tissue distribution of human and murine CXCL14, distinct differences point to diverse, species-specific needs for CXCL14 in epithelial immunity. PMID: 18809336
  13. findings demonstrate that early overexpression of PMP22 in a mouse model of Charcot-Marie-Tooth disease type 1A results in a strong up-regulation of CXCL14 which seems to play a novel regulatory role in Schwann cell differentiation PMID: 19111616
  14. CXCL14 is an important paracrine/autocrine modulator regulating trophoblast outgrowth at the maternal-fetal interface during the process of pregnancy establishment. PMID: 19626669
  15. These data indicate the possibility that BRAK expression inhibits tumor cell establishment by regulating interactions between tumor stem cells and NK cells and/or suppressing formation of tumor microvessels. PMID: 19887729

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Subcellular Location Secreted.
Protein Families Intercrine alpha (chemokine CxC) family
Tissue Specificity Highly expressed in brain, lung, ovary, muscle and in kidney and liver parenchyma, and at lower levels in bone marrow.
Database Links

KEGG: mmu:57266

STRING: 10090.ENSMUSP00000021970

UniGene: Mm.30211

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