Your Good Partner in Biology Research
Tel : 301-363-4651
Your Good Partner in Biology Research
| Code | CSB-PA823464LD01HU |
| Size | US$299 |
| Uniprot No. | Q8TDM6 |
| Protocols | ELISA Protocol |
| Immunogen | Recombinant Human Disks large homolog 5 protein (1580-1704AA) |
| Raised in | Rabbit |
| Species Reactivity | Human |
| Tested Applications | ELISA |
| Relevance | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). |
| Form | Liquid |
| Conjugate | Biotin |
| Storage Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method | >95%, Protein G purified |
| Isotype | IgG |
| Clonality | Polyclonal |
| Alias | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG), DLG5, KIAA0583 PDLG |
| Immunogen Species | Homo sapiens (Human) |
| Research Area | Signal Transduction |
| Target Names | DLG5 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Function | Acts as a regulator of the Hippo signaling pathway |
| Subcellular Location | Cell junction, Cell membrane, Peripheral membrane protein, Cell junction, synapse, postsynaptic cell membrane, postsynaptic density, Cytoplasm, cytoskeleton, cilium basal body |
| Protein Families | MAGUK family |
| Tissue Specificity | Highly expressed in normal breast tissues and low-grade breast cancer tissues (at protein level) (PubMed:28169360). Highly expressed in the placenta and prostate. Expressed at a lower level in the thyroid, spinal cord, trachea, adrenal gland, skeletal mus |
| Database Links |
HGNC: 2904 OMIM: 604090 KEGG: hsa:9231 STRING: 9606.ENSP00000361467 UniGene: Hs.652690 |
DLG5 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA006939GA01HU | DLG5 Antibody | Human,Mouse | ELISA,WB |
| CSB-PA823464LA01HU | DLG5 Antibody | Human | ELISA, IF |
| CSB-PA823464LB01HU | DLG5 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA823464LC01HU | DLG5 Antibody, FITC conjugated | Human | ELISA |
DLG5 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP823464HU CSB-EP823464HU CSB-BP823464HU CSB-MP823464HU |
Recombinant Human Disks large homolog 5(DLG5) ,partial | Yeast E.coli Baculovirus Mammalian cell |
2-hydroxyisobutyryl-HIST1H1C (K116) Antibody
Applications: ELISA, ICC, IF, ChIP
Species Reactivity: Human
2-hydroxyisobutyryl-HIST1H2BC (K12) Antibody
Applications: ELISA, WB, ICC, IF
Species Reactivity: Human
2-hydroxyisobutyryl-HIST1H3A (K18) Antibody
Applications: ELISA, WB, ICC, IF
Species Reactivity: Human
