DLG5 Antibody, FITC conjugated

Code CSB-PA823464LC01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) DLG5 Polyclonal antibody
Uniprot No. Q8TDM6
Target Names DLG5
Alternative Names Discs large homolog 5 (Drosophila) antibody; Discs large homolog 5 antibody; Discs large protein LP DLG antibody; Discs large protein P dlg antibody; Discs large protein P-dlg antibody; Disks large homolog 5 antibody; DLG 5 antibody; DLG5 antibody; DLG5_HUMAN antibody; KIAA0583 antibody; Large type of P DLG antibody; LP DLG antibody; P DLG5 antibody; PDLG antibody; Placenta and prostate DLG antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Disks large homolog 5 protein (1580-1704AA)
Immunogen Species Homo sapiens (Human)
Conjugate FITC
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Acts as a regulator of the Hippo signaling pathway
Gene References into Functions
  1. Loss of DLG5 expression promoted breast cancer progression by inactivating the Hippo signaling pathway and increasing nuclear YAP. PMID: 28169360
  2. both polymorphisms of DLG5 are correlated with inflammatory bowel disease susceptibility in an ethnic-specific manner. PMID: 27633114
  3. Low expression of DLG5 is associated with Crohn's disease. PMID: 27760079
  4. Data found that Dlg5 expression was significantly lower in human hepatocellular carcinoma (HCC) tissues and indicate that Dlg5 acts as a novel regulator of invadopodium-associated invasion via Girdin and by interfering with the interaction between Girdin and Tks5, which might be important for Tks5 phosphorylation in HCC cells. PMID: 28390157
  5. G113A variant may be significantly associated with Crohn's disease risk in children and colonic involvement (Meta-Analysis) PMID: 27338058
  6. DLG5 inhibits the association between MST1/2 and large tumor suppressor homologs 1/2 (LATS1/2), uses its scaffolding function to link MST1/2 with MARK3, and inhibits MST1/2 kinase activity PMID: 28087714
  7. Pooled data indicated no significant association between DLG5113G/A gene polymorphism and the development of Crohn's disease PMID: 27309475
  8. These data suggest that inhibition of Dlg5 by DNA hypermethylation contributes to provoke invasive phenotypes in bladder tumor. PMID: 25478998
  9. Findings demonstrate that Dlg5 interacts with and inhibits the activity of Girdin, thereby suppressing the migration of prostate cancer cells. PMID: 24662825
  10. DLG5 plays a role in cell migration, cell adhesion, precursor cell division, cell proliferation, epithelial cell polarity maintenance, and transmission of extracellular signals to the membrane and cytoskeleton. PMID: 24910533
  11. Overexpression of Dlg5 enhances the degradation of TGFBRI. PMID: 23624079
  12. Polymorphisms in the DLG5 gene were found to be associated with Crohn's disease patients in Malaysia. PMID: 22118696
  13. Examined the genetic association of DLG5 SNP P1371Q with inflammatory bowel disease and its interaction with R30Q in disease susceptibility. P1371Q is complementary to R30Q, with R30Q exhibiting a dominant effect in IBD susceptibility. PMID: 22065243
  14. Increased expression of discs large homolog 5 gene is associated with ulcerative colitis. PMID: 21674725
  15. In the studied population, DLG5 R30Q was associated with all forms of IBD. An elevated presence of the R30Q variant was observed in all members of a familial IBD registry PMID: 20037206
  16. findings suggest that lp-dlg/KIAA0583 is a novel scaffolding protein that can link the vinexin-vinculin complex and beta-catenin at sites of cell-cell contact PMID: 12657639
  17. Genetic variation in DLG5 is associated with inflammatory bowel disease PMID: 15107852
  18. Collaboration of RAB6KIFL and DLG5 is likely to be involved in pancreatic cancer. PMID: 15665285
  19. DLG5 constitutes a true inflammatory bowel diseases risk factor of modest effect PMID: 15841097
  20. there are significant population allele frequency differences at the DLG5 gene [letter] PMID: 16391570
  21. The G113A polymorphism of the DLG5 gene was completely absent in Greek Crohn disease cases as well as the Greek healthy population PMID: 16437728
  22. R30Q variant constitutes a susceptibility factor for Crohn disease (CD) in men. PMID: 16446977
  23. The results indicate a role for DLG5 variants in inflammatory bowel disease (IBD) susceptibility. PMID: 16450402
  24. The initial report of DLG5 as a novel inflammatory bowel disease (IBD) susceptibility gene sparked a multitude of studies concerning its role in the aetiology of Crohn disease and IBD. PMID: 16773680
  25. The R30Q variant in the DLG5 gene does not appear to be associated with an overall increase in the risk of disease in a British IBD cohort PMID: 16944184
  26. DLG5 has a gender-specific role in the susceptibility of pediatric CD. Significant negative association found between DLG5 R30Q and CD in female children suggests DLG5 may have a protective effect in CD susceptibility for female children. PMID: 17156146
  27. DLG5 gene missense mutation is associated with increased susceptibility to inflammatory bowel diseases in children. PMID: 17307543
  28. polymorphism exerts a weak influence on Crohn's disease phenotype PMID: 17451203
  29. the DLG5 haplotype A is associated with reduced risk of inflammatory bowel disease in the New Zealand Caucasian population PMID: 17455201
  30. polymorphisms 3020insC in CARD15 and SNP rs2165047 in DLG5 may have a role in pediatric-onset Crohn's disease PMID: 17476680
  31. DLG5 30Q is associated with a small reduction in risk of Crohn disease in women in a Caucasian cohort. PMID: 17693570
  32. Results provide evidence that the scaffolding protein DLG5 belongs to the CARD protein family. PMID: 18335190
  33. findings show that the inflammatory bowel disease-susceptibility gene DLG5 is also associated with gluten-sensitive enteropathy PMID: 18559397

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Subcellular Location Cell junction, Cell membrane, Peripheral membrane protein, Cell junction, synapse, postsynaptic cell membrane, postsynaptic density, Cytoplasm, cytoskeleton, cilium basal body
Protein Families MAGUK family
Tissue Specificity Highly expressed in normal breast tissues and low-grade breast cancer tissues (at protein level) (PubMed:28169360). Highly expressed in the placenta and prostate. Expressed at a lower level in the thyroid, spinal cord, trachea, adrenal gland, skeletal mus
Database Links

HGNC: 2904

OMIM: 604090

KEGG: hsa:9231

STRING: 9606.ENSP00000361467

UniGene: Hs.652690

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