DMRT1 Antibody, HRP conjugated

Code CSB-PA896914LB01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) DMRT1 Polyclonal antibody
Uniprot No. Q9Y5R6
Target Names DMRT1
Alternative Names CT154 antibody; DM domain expressed in testis 1 antibody; DM domain expressed in testis protein 1 antibody; DM domain gene expressed in testis antibody; DMRT 1 antibody; dmrt1 antibody; DMRT1_HUMAN antibody; DMT 1 antibody; DMT1 antibody; Doublesex and mab 3 related transcription factor 1 antibody; Doublesex- and mab-3-related transcription factor 1 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Doublesex- and mab-3-related transcription factor 1 protein (195-363AA)
Immunogen Species Homo sapiens (Human)
Conjugate HRP
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator
Gene References into Functions
  1. DMRT1 might influence sex-specific patterns of childhood asthma, and its expression in testis tissue and lung macrophages suggests a potential involvement in hormone or immune cell regulation. PMID: 26906082
  2. The results suggest a role of changes in DMRT1 dosage in non-obstructive azoospermia potentially also through a process of gene misregulation, even though DMRT1 deleterious variants seem to be rare. PMID: 26139570
  3. The role of DMT1 in mitochondrial iron acquisition by immunofluorescence with mitochondrial markers in cells and isolated mitochondria, as well as flow cytometric quantification of DMT1-positive mitochondria from an inducible expression system. PMID: 25483589
  4. These show that DMRT proteins use a unique binding interaction, inserting two adjacent antiparallel recognition helices into a widened DNA major groove to make base-specific contacts. PMID: 26005864
  5. Point mutations of DMRT1 may be rarely associated with male infertility. PMID: 24934491
  6. The combined results indicate that DMRT1 loss-of-function mutations are a risk factor and potential genetic cause of human spermatogenic failure PMID: 23555275
  7. neither DMRT1 nor FGF9 abnormalities are frequently involved in dysgenetic male gonad development in patients with non-syndromic 46,XY disorder of sex development. PMID: 22939835
  8. Meiosis signalling is dysregulated in carcinoma in situ (CIS) cells and that a key regulator of the mitosis-meiosis switch, DMRT1, is expressed in 'early-stage' CIS cells but is down-regulated with further invasive transformation. PMID: 23303528
  9. The biological importance of the changes in expression of DMRT1 in Sertoli cells remains to be established, but it is consistent with DMRT1 reinforcing the inhibition of meiosis in the testis. PMID: 22899867
  10. Findings continue to corroborate that genes influencing male germ cell development and differentiation have emerged as the major players in inherited TGCT susceptibility. PMID: 21551455
  11. variants in or near BAK1, DMRT1, TERT-CLPTM1L, and KITLG predispose to familial and bilateral TGCT. PMID: 21617256
  12. There is evidence that DMT1 expression and function respond rapidly to changes in dietary iron content PMID: 21462105
  13. Chromosome 9p loss is the hallmark of squamous cell carcinoma, and DMRT1, DMRT3 and DOCK8 genes at 9p24.3 might be of interest for the study of the pathophysiology of SCC as potential targets for therapeutic measures. PMID: 20596660
  14. Studies identified three new susceptibility loci DMRT1, TERT and ATF7IP associated with testicular germ cell cancer. PMID: 20543847
  15. Analysis of germ cell tumors reveals gene expression changes correlated to DMRT1 levels. PMID: 20007774
  16. Comparison of genomic and mRNA sequences show that DMRT1b and c result from exonization of intronic sequences, including the exonization of an Alu element. All 99 Alu elements are non-randomly distributed among the non-coding regions on both directions. PMID: 16617334

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Involvement in disease Testicular germ cell tumor (TGCT); 46,XY sex reversal 4 (SRXY4)
Subcellular Location Nucleus
Protein Families DMRT family
Tissue Specificity Testis-specific. Expressed in prostate cancer (at protein level).
Database Links

HGNC: 2934

OMIM: 154230

KEGG: hsa:1761

STRING: 9606.ENSP00000371711

UniGene: Hs.98586

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