FGFRL1 Antibody, Biotin conjugated

Code CSB-PA008650LD01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) FGFRL1 Polyclonal antibody
Uniprot No. Q8N441
Target Names FGFRL1
Alternative Names FGF homologous factor receptor antibody; FGF receptor like protein 1 antibody; FGF receptor-like protein 1 antibody; FGFR 5 antibody; FGFR like protein antibody; FGFR-5 antibody; FGFR-like protein antibody; FGFR5 antibody; Fgfrl1 antibody; FGRL1_HUMAN antibody; FHFR antibody; Fibroblast growth factor receptor 5 antibody; Fibroblast growth factor receptor like 1 antibody; Fibroblast growth factor receptor-like 1 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Fibroblast growth factor receptor-like 1 protein (403-470AA)
Immunogen Species Homo sapiens (Human)
Conjugate Biotin
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

(From Uniprot)
Has a negative effect on cell proliferation.
Gene References into Functions
  1. this study shows FGFRL1 promotes ovarian cancer progression by crosstalk with Hedgehog signaling PMID: 29675438
  2. FGFRL1 is a transmembrane receptor that can induce the fusion of CHO cells to multinucleated syncytia. This cell fusion activity has been attributed to the extracellular Ig3 domain of the receptor. The Ig3 domain from humans, mice, chicken and fish stimulates fusion of CHO cells, while the Ig3 domain from lancelet and sea urchin does not. PMID: 28596102
  3. Both in vitro and in vivo studies determined that miR-210 promoted hepatocellular carcinoma (HCC), angiogenesis, and the corresponding mechanism was identified to be the direct targeting and inhibition of fibroblast growth factor receptor-like 1 (FGFRL1) expression PMID: 27666683
  4. FGFRL1 is a cell adhesion protein. PMID: 27220341
  5. functional evidence for a novel FGFRL1 poly-miRTS rs4647940 in a previously known 4p16.3 locus, and experimental and clinical genetics studies have shown both FGFRL1 and hsa-miR-140-5p are important for bone formation. PMID: 25941324
  6. Cell-cell fusion induced by the Ig3 domain of receptor FGFRL1 PMID: 26025674
  7. The signaling complex appears to integrate the input from FGFR and EphA4, and release the output signal through FRS2alpha. PMID: 20184660
  8. study identified a novel region of deletion mapping to 4p16.3 in 15 percent of bladder tumors and 24 percent of bladder cancer cell lines; FGFRL1, which maps within this region, was investigated as putative deletion target; average FGFRL1 protein expression was lower in bladder tumors compared to normal tissue, but downregulation was independent from 4p16.3 LOH status PMID: 23775577
  9. Interaction of FGFRL1 with Spred1 increases the proportion of the receptor at the plasma membrane. PMID: 21616146
  10. an important role for miR-210 as a tumor-suppressive microRNA with effects on cancer cell proliferation PMID: 21044961
  11. FGFRL1 is capable of inducing syncytium formation of heterologous cells in vitro. PMID: 20851884
  12. FGFRL1 is indeed a decoy receptor for FGFs. PMID: 19920134
  13. analysis of FGF18 and FGFR5(FGFRL1) expression in primary endothelial cells and vascular smooth muscle cells PMID: 16019430
  14. Screening of 241 different human tumors with the help of a cancer profiling array suggested major alterations in the relative expression of FGFRL1 in ovarian tumors PMID: 16273302
  15. The extracellular domain of recombinant FGFRL1 promoted cell adhesion, but not cell spreading. Adhesion was mediated by heparan sulfate glycosaminoglycans located at the cell surface. PMID: 18061161
  16. mutant FGFRL1 contributes to the skeletal malformations of the patient PMID: 19056490

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Subcellular Location Membrane; Single-pass type I membrane protein. Note=Predominantly localized in the plasma membrane but also detected in the Golgi and in secretory vesicles.
Tissue Specificity Expressed preferentially in cartilaginous tissues and pancreas. Highly expressed in the liver, kidney, heart, brain and skeletal muscle. Weakly expressed in the lung, small intestine and spleen.
Database Links

HGNC: 3693

OMIM: 605830

KEGG: hsa:53834

STRING: 9606.ENSP00000264748

UniGene: Hs.193326


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