HOOK3 Antibody, HRP conjugated

Datasheet
Code CSB-PA769790LB01HU
Size US$299
Uniprot No. Q86VS8
Protocols ELISA Protocol
Immunogen Recombinant Human Protein Hook homolog 3 protein (357-455AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494).
Form Liquid
Conjugate HRP
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Protein Hook homolog 3 (h-hook3) (hHK3), HOOK3
Immunogen Species Homo sapiens (Human)
Research Area Signal Transduction
Target Names HOOK3
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track)
Subcellular Location Cytoplasm, cytoskeleton, Golgi apparatus
Protein Families Hook family
Database Links

HGNC: 23576

OMIM: 607825

KEGG: hsa:84376

STRING: 9606.ENSP00000305699

UniGene: Hs.162852

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