ID2 Antibody

Datasheet
Code CSB-PA010967KA01HU
Product Type Rabbit Anti Human PolyClonal Antibody
Size US$398
Uniprot No. Q02363
Image
  • Western blot analysis of 293T cell lysate using ID2 antibody.
Immunogen Recombinant protein of Human ID2
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,WB,IHC;WB:1:500-1:2000,IHC:1:50-1:200
Relevance Inhibitor of DNA-binding-2 (Id2) is a member of the Id proteins which belong to the helix-loop-helix (HLH) protein family. The Id protein functions by binding to specific transcription factors and preventing their dimerization and DNA binding. Id2 interacts with a wide variety of transcription factors including E proteins, TCS, Pax and the tumor suppressor Rb. Id2 has been shown to be important in regulating cellular differentiation, proliferation, development and tumorgenesis. In tumor cells, increased levels of Id2 functionally inactivate Rb, leading to cellular transformation and cancer. Id2 is therefore a promising therapeutic target for treatment of cancer.
Storage Buffer Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method Affinity purification
Isotype IgG
Alias ID2;GIG8;ID2A;ID2H;MGC26389;bHLHb26
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Research Area Epigenetics and Nuclear Signaling
Intended Use For research use only. Not for human, diagnostic or therapeutic use.
Target Names ID2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Details This protein belongs to the inhibitor of DNA binding (ID) family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the ID family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene has been identified for this gene.
HGNC 5361
RGD 2859
MGI 96397
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Function Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock
Subcellular Location Cytoplasm, Nucleus
Tissue Specificity Highly expressed in early fetal tissues, including those of the central nervous system.
Database Links

HGNC: 5361

OMIM: 600386

KEGG: hsa:3398

STRING: 9606.ENSP00000234091

UniGene: Hs.180919

Pathway Hippo signaling pathway
TGF-beta signaling pathway
Signaling pathways regulating pluripotency of stem cells

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