Name: IL1F10 Antibody, HRP conjugated
Brand: CUSABIO
SKU: CSB-PA837869HB01HU

Product Details

Full Product Name	Rabbit anti-Homo sapiens (Human) IL1F10 Polyclonal antibody
Uniprot No.	Q8WWZ1
Target Names	IL1F10
Alternative Names	family of interleukin 1-theta antibody; FIL1 theta antibody; FIL1T antibody; FKSG75 antibody; IL 38 antibody; IL-1 theta antibody; IL-1F10 (canonical form IL-1F10a) antibody; IL-1F10 antibody; IL-1HY2 antibody; IL1 theta antibody; IL1F10 antibody; IL1FA_HUMAN antibody; IL1HY2 antibody; Interleukin 1 family member 10 (theta) antibody; Interleukin 1 receptor antagonist FKSG75 antibody; Interleukin 1 receptor antagonist homolog 2 antibody; Interleukin 1 receptor antagonist like FIL1 theta antibody; Interleukin-1 family member 10 antibody; Interleukin-1 HY2 antibody; Interleukin-1 theta antibody; interleukin-38 antibody
Raised in	Rabbit
Species Reactivity	Human
Immunogen	Recombinant Human Interleukin-1 family member 10 protein (1-152AA)
Immunogen Species	Homo sapiens (Human)
Conjugate	HRP
Clonality	Polyclonal
Isotype	IgG
Purification Method	>95%, Protein G purified
Concentration	It differs from different batches. Please contact us to confirm it.
Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form	Liquid
Tested Applications	ELISA
Protocols	ELISA Protocol
Troubleshooting and FAQs	Antibody FAQs
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time	Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function	Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2.
Gene References into Functions	The serum level of IL-38 in the children in the acute phase of Kawasaki disease was significantly lower than that in the healthy control group PMID: 30022755 IL-38 may play an important role in acute and/or chronic inflammation in anticancer drug-induced lung injury and acute exacerbation of idiopathic pulmonary fibrosis. PMID: 28942884 IL-38 may exert its anti-inflammatory effects by decreasing the production of proinflammatory cytokines by macrophages and synovial fibroblasts. PMID: 28288964 this clinical study demonstrates the elevation of anti-inflammatory cytokine IL-38 and the decrement of CD4+CD25highFoxP3+ and CD4+CD25highCD127- Treg in childhood asthma. The negative correlation of IL-38 and Treg lymphocytes may imply a negative feedback of the two anti-inflammatory factors in asthma. PMID: 27438823 this study shows that in vivo expression of human IL-38 in mice has hepatoprotective effects against Con A-induced liver injury by inhibition of inflammatory cytokine production PMID: 27723569 Higher serum IL-38 levels before treatment indicate a greater probability of viral response to telbivudine treatment in chronic hepatitis B. PMID: 27182162 results indicate that circulating IL-38 is a potentially novel biomarker for patients with ST-segment elevation myocardial infarction PMID: 26819499 Data suggest that IL-38 may be protective in SLE. A strong association between IL-38 and SLE severity suggests that IL-38 expression is driven by processes linked to SLE pathogenesis. PMID: 26314375 rs6759676, closest gene locus IL1F10 is associated with increased circulating levels of IL-1 receptor antagonist, a protective factor in development of insulin resistance. PMID: 24969107 The IL1A locus was strongly associated with alkylosing spondyloarthritis phenotype, whereas IL1F10 was associated with non-alkylosing spondyloarthritis. PMID: 22312160 These data provide evidence that IL-38 binds to the IL-36R, as does IL-36Ra.[IL-38, IL-36R] PMID: 22315422 Show More Hide All
Subcellular Location	Secreted
Protein Families	IL-1 family
Tissue Specificity	Expressed in fetal skin, spleen and tonsil. Expressed mostly in the basal epithelia of skin and in proliferating B-cells of the tonsil.
Database Links	HGNC: 15552 OMIM: 615296 KEGG: hsa:84639 STRING: 9606.ENSP00000341794 UniGene: Hs.306974

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Code	CSB-PA837869HB01HU
Size	US$299
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IL1F10 Antibody, HRP conjugated

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