KLRD1 Antibody, HRP conjugated

Code CSB-PA615672LB01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) KLRD1 Polyclonal antibody
Uniprot No. Q13241
Target Names KLRD1
Alternative Names CD 94 antibody; CD94 antibody; CD94 antigen antibody; Killer cell lectin like receptor subfamily D member 1 antibody; Killer cell lectin-like receptor subfamily D member 1 antibody; KLRD 1 antibody; KLRD1 antibody; KLRD1 protein antibody; KLRD1_HUMAN antibody; KP 43 antibody; KP43 antibody; Natural killer cells antigen CD94 antibody; NK cell receptor antibody; OTTHUMP00000238754 antibody; OTTHUMP00000238755 antibody; OTTHUMP00000238756 antibody; OTTHUMP00000238758 antibody; OTTHUMP00000239093 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Natural killer cells antigen CD94 protein (42-168AA)
Immunogen Species Homo sapiens (Human)
Conjugate HRP
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
Gene References into Functions
  1. an early response by KLRD1-expressing Natural killer cells may control influenza infection. PMID: 29898768
  2. it is not clear if high expression of CD94 on peripheral blood NK cells is related to abnormal activity of endometrial NK cells. PMID: 24975965
  3. Synergistic inhibition of natural killer cells by the nonsignaling molecule CD94. PMID: 24082146
  4. Studies indicate that HLA-E interacts with CD94/NKG2 receptors expressed mainly on the surface of natural killer (NK) cells, thus confining its role to the regulation of NK-cell function. PMID: 22576308
  5. Loss of CD94 is associated with rheumatoid arthritis. PMID: 22102879
  6. increased expression on natural killer cells in women with recurrent spontaneous abortion after IVIG therapy PMID: 19811464
  7. human CD56(bright) NK cells progress through a continuum of differentiation that ends with a CD94(low)CD56(dim) phenotype. PMID: 19897577
  8. Conservation and variation in human and chimpanzee CD94 genes PMID: 11751968
  9. A critical role of CD94-dependent MHC-I recognition for the regulation of IFN-gamma production and target lysis was demonstrated. PMID: 12149421
  10. TCR specificity dictates CD94/NKG2A expression by CTL. PMID: 12387742
  11. CD94 gene expression is regulated by distal and proximal promoters that transcribe unique initial exons specific to each promoter, resulting in two species of transcripts--the previously described CD94 mRNA and a novel CD94C mRNA. PMID: 14607929
  12. Aberrant expression of natural killer (NK) receptors CD94/NKG2A may have an impact on the magnitude and direction of dendritic cell activation of T cells under pathological conditions, such as chronic hepatitis C virus infection. PMID: 15528343
  13. A CD94 alternatively spliced transcript paired with an NKG2B isoform may contribute to the plasticity of the natural killer cell immunological synapse by insuring an adequate inhibitory signal. PMID: 16237464
  14. Cytolytic activity levels of purified CD94-expressing cells from 7-day cultures with FK506 were much higher than those from 7-day cultures without FK506. PMID: 16378079
  15. results indicate that the SNPs of the inhibitory receptor CD94/NKG2A and its haplotypes, as well as its ligand HLA-E, are associated with Behcet's disease immune systems PMID: 17767552
  16. identified molecular characteristics of an aggressive subset of pediatric patients with AML through a prospective evaluation of CD56+ neural cell adhesion molecule (NCAM) and CD94 expression PMID: 18323797
  17. Uncommon endocytic and trafficking pathway of the natural killer cell CD94/NKG2A inhibitory receptor is described. PMID: 18363778
  18. Under the influence of interleukin-12 stimulation, CD94/NKG2A is transiently inducible in natural killer (NK) cells bearing the homologous CD94/NKG2C-activating receptor, providing a potential negative regulatory feedback mechanism. PMID: 19124726
  19. In this work, the glycan ligands of NKG2D and CD94 for the first time were resolved. PMID: 19303396
  20. NKG2D and CD94 bind to heparin and sulfate-containing polysaccharides. PMID: 19555665

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Subcellular Location Membrane, Single-pass type II membrane protein
Tissue Specificity Natural killer cells.
Database Links

HGNC: 6378

OMIM: 602894

KEGG: hsa:3824

STRING: 9606.ENSP00000338130

UniGene: Hs.562457

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