MLKL Antibody, Biotin conjugated

Datasheet
Code CSB-PA850851LD01HU
Size US$299
Uniprot No. Q8NB16
Protocols ELISA Protocol
Immunogen Recombinant Human Mixed lineage kinase domain-like protein (1-471AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Mixed lineage kinase domain-like protein (hMLKL), MLKL
Immunogen Species Homo sapiens (Human)
Research Area Signal Transduction
Target Names MLKL
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
Subcellular Location Cytoplasm, Cell membrane
Protein Families Protein kinase superfamily
Database Links

HGNC: 26617

OMIM: 615153

KEGG: hsa:197259

STRING: 9606.ENSP00000308351

UniGene: Hs.119878

Pathway TNF signaling pathway
Necroptosis

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